siRNA, Anti-LARGE1, 2'-F/2'-OMe/2'-MOE/LNA/Ribo/Backbone-modified(CAT#: SIRGT26865WQ-2OMe)
The product SIRGT26865WQ-2OMe is a type of small interfering RNA (siRNA) that targets LARGE1 gene and regulates the expression of gene. The siRNA interferes with the expression of LARGE1 gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. The siRNA is designed with 2ʹ-O-methyl (2'-OMe) modification to provide increased stability, increased specificity and reduced immunogenicity. It has potential applications in RNA interference (RNAi) and gene therapy development.
| Specifications | |
|---|---|
| NCBI RefSeq | NM_004737.5; NM_133642.3 |
| Alternative Names | LARGE; MDC1D; MDDGA6; MDDGB6 |
| Related Diseases | Muscular Dystrophy-Dystroglycanopathy |
| Purification | HPLC |
| Sub Cat | Target | Species | Modification | Scale | |
|---|---|---|---|---|---|
| SIRGT27865WQ-2F | LARGE1 | Human | 2ʹ-deoxy-2ʹ-fluoro (2'-F) | ||
| SIRGT28865WQ-2MOE | LARGE1 | Human | 2'-O-methoxyethyl (2'-MOE) | ||
| SIRGT29865WQ-LNA | LARGE1 | Human | Locked Nucleic Acid (LNA) | ||
| SIRGT26865WQ-RB | LARGE1 | Human | Ribo-modified | ||
| SIRGT27865WQ-BB | LARGE1 | Human | Backbone-modified |
