siRNA, Anti-NDUFA4, 2'-F/2'-OMe/2'-MOE/LNA/Ribo/Backbone-modified(CAT#: SIRGT11967WQ-2OMe)

The product SIRGT11967WQ-2OMe is a type of small interfering RNA (siRNA) that targets NDUFA4 gene and regulates the expression of gene. The siRNA interferes with the expression of NDUFA4 gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. The siRNA is designed with 2ʹ-O-methyl (2'-OMe) modification to provide increased stability, increased specificity and reduced immunogenicity. It has potential applications in RNA interference (RNAi) and gene therapy development.

Specifications
NCBI RefSeq NM_002489.3
Alternative Names CI-9k; CI-MLRQ; MLRQ
Related Diseases Leigh Syndrome With Leukodystrophy
Purification HPLC
Target Gene
Gene ID 4697
Uniprot ID O00483
Sub Cat Target Species Modification Scale  
SIRGT12967WQ-2F NDUFA4 Human 2ʹ-deoxy-2ʹ-fluoro (2'-F) Inquiry
SIRGT13967WQ-2MOE NDUFA4 Human 2'-O-methoxyethyl (2'-MOE) Inquiry
SIRGT14967WQ-LNA NDUFA4 Human Locked Nucleic Acid (LNA) Inquiry
SIRGT11967WQ-RB NDUFA4 Human Ribo-modified Inquiry
SIRGT12967WQ-BB NDUFA4 Human Backbone-modified Inquiry

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