siRNA, Anti-TTR, 2'-F/2'-OMe/2'-MOE/LNA/Ribo/Backbone-modified(CAT#: SIRGT21770WQ-2OMe)
The product SIRGT21770WQ-2OMe is a type of small interfering RNA (siRNA) that targets TTR gene and regulates the expression of gene. The siRNA interferes with the expression of TTR gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. The siRNA is designed with 2ʹ-O-methyl (2'-OMe) modification to provide increased stability, increased specificity and reduced immunogenicity. It has potential applications in RNA interference (RNAi) and gene therapy development.
| Specifications | |
|---|---|
| NCBI RefSeq | NM_000371.3 |
| Alternative Names | ATTR; CTS; CTS1; HEL111; HsT2651; PALB; TBPA |
| Related Diseases | Amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis |
| Purification | HPLC |
| Sub Cat | Target | Species | Modification | Scale | |
|---|---|---|---|---|---|
| SIRGT22770WQ-2F | TTR | Human | 2ʹ-deoxy-2ʹ-fluoro (2'-F) | ||
| SIRGT23770WQ-2MOE | TTR | Human | 2'-O-methoxyethyl (2'-MOE) | ||
| SIRGT24770WQ-LNA | TTR | Human | Locked Nucleic Acid (LNA) | ||
| SIRGT21770WQ-RB | TTR | Human | Ribo-modified | ||
| SIRGT22770WQ-BB | TTR | Human | Backbone-modified |
