siRNA, Anti-ZIC4, 2'-F/2'-OMe/2'-MOE/LNA/Ribo/Backbone-modified(CAT#: SIRGT46781WQ-2OMe)

The product SIRGT46781WQ-2OMe is a type of small interfering RNA (siRNA) that targets ZIC4 gene and regulates the expression of gene. The siRNA interferes with the expression of ZIC4 gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. The siRNA is designed with 2ʹ-O-methyl (2'-OMe) modification to provide increased stability, increased specificity and reduced immunogenicity. It has potential applications in RNA interference (RNAi) and gene therapy development.

Specifications
NCBI RefSeq NM_001168378.1
Related Diseases Isolated Dandy-Walker Malformation With Hydrocephalus
Purification HPLC
Target Gene
Gene ID 84107
Uniprot ID Q8N9L1
Sub Cat Target Species Modification Scale  
SIRGT47781WQ-2F ZIC4 Human 2ʹ-deoxy-2ʹ-fluoro (2'-F) Inquiry
SIRGT48781WQ-2MOE ZIC4 Human 2'-O-methoxyethyl (2'-MOE) Inquiry
SIRGT49781WQ-LNA ZIC4 Human Locked Nucleic Acid (LNA) Inquiry
SIRGT46781WQ-RB ZIC4 Human Ribo-modified Inquiry
SIRGT47781WQ-BB ZIC4 Human Backbone-modified Inquiry

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