siRNA, Anti-CACNA1B, 2'-F/2'-MOE/Ribo/Backbone-modified(CAT#: SIRGT02519WQ-2F)
The product SIRGT02519WQ-2F is a type of small interfering RNA (siRNA) that targets CACNA1B gene and regulates the expression of gene. The siRNA interferes with the expression of CACNA1B gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. The siRNA is designed with 2ʹ-deoxy-2ʹ-fluoro (2'-F) modification to provide increased stability, increased specificity and reduced immunogenicity. It has potential applications in RNA interference (RNAi) and gene therapy development.
| Specifications | |
|---|---|
| NCBI RefSeq | NM_000718.3; NM_001243812.1 |
| Alternative Names | BIII; CACNL1A5; CACNN; Cav2.2; DYT23 |
| Related Diseases | Neurodevelopmental Disorder With Seizures, Nonepileptic Hyperkinetic Movements |
| Purification | HPLC |
| Sub Cat | Target | Species | Modification | Scale | |
|---|---|---|---|---|---|
| SIRGT03519WQ-2MOE | CACNA1B | Human | 2'-O-methoxyethyl (2'-MOE) | ||
| SIRGT01519WQ-RB | CACNA1B | Human | Ribo-modified | ||
| SIRGT02519WQ-BB | CACNA1B | Human | Backbone-modified |
