siRNA, Anti-HLA-DOA, 2'-OMe/LNA/Ribo/Backbone-modified(CAT#: SIRGT11037WQ-2OMe)
The product SIRGT11037WQ-2OMe is a type of small interfering RNA (siRNA) that targets HLA-DOA gene and regulates the expression of gene. The siRNA interferes with the expression of HLA-DOA gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. The siRNA is designed with 2ʹ-O-methyl (2'-OMe) modification to provide increased stability, increased specificity and reduced immunogenicity. It has potential applications in RNA interference (RNAi) and gene therapy development.
| Specifications | |
|---|---|
| NCBI RefSeq | NM_002119.3 |
| Alternative Names | HLA-DNA; HLA-DZA; HLADZ |
| Related Diseases | Keshan Disease, Hirata Disease |
| Purification | HPLC |
| Sub Cat | Target | Species | Modification | Scale | |
|---|---|---|---|---|---|
| SIRGT14037WQ-LNA | HLA-DOA | Human | Locked Nucleic Acid (LNA) | ||
| SIRGT11037WQ-RB | HLA-DOA | Human | Ribo-modified | ||
| SIRGT12037WQ-BB | HLA-DOA | Human | Backbone-modified |
