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EXPLORE MORECreative Biolabs has a tradition of commitment. To achieve efficient execution and regulatory approval, we offer careful considerations of your program for the development of a cellular or gene therapy product – now and in the future.
EXPLORE MOREWe focus on unmet needs and develop novel cellular and gene drugs and solutions that offer significant benefits over existing options.
EXPLORE MORETo accelerate advanced breakthroughs of your projects, we offer broad range of platforms which enable our clients be free to tackle problems with cutting-edge technologies from different angles and in different methods.
EXPLORE MOREUse the resources in our library to help you understand your options and make critical decisions for your study. We offer oncolytic virus, CAR-T, and dendritic cell related documents, as well as newsletter. If you don’t find the answers you’re looking for, contact us for additional assistance.
EXPLORE MORECarcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) also known as CD66e (Cluster of Differentiation 66e), is a protein encoded by CEACAM5 gene in human. Carcinoembryonic antigen (CEA) describes a set of highly related glycoproteins involved in cell adhesion. CEA is normally produced in gastrointestinal tissue during fetal development, but the production stops before birth. Therefore, CEA is usually present only at very low levels in the blood of healthy adults. However, the serum levels are raised in some types of cancer, so that CEA usually act as a tumor marker in clinical test. CEA are glycosyl phosphatidyl inositol (GPI) cell-surface-anchored glycoproteins whose specialized sialofucosylated glycoforms serve as functional colon carcinoma L-selectin and E-selectin ligands, which may be critical to the metastatic dissemination of colon carcinoma cells.
Associated Disease
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| CAT | Product Name | Target Species | Antibody Clone | Antibody Host | Receptor Construction | Vector Type | Targeting Cell Type | Inquiry & Datasheet |
| CAR-T-1-M314-2 | Anti-CEA scFv h(CD28) CART, pCDCAR1 | Human | BW431/26 | Human | scFv-CD28 | Lentiviral | T cell | |
| CAR-T-1-M314-G | Anti-CEA scFv h(FcεRIγ) CART, pCDCAR1 | Human | BW431/26 | Human | scFv-FcεRIγ | Lentiviral | T cell | |
| CAR-T-1-M314-Z | Anti-CEA scFv h(CD3ζ) CART, pCDCAR1 | Human | BW431/26 | Human | scFv-CD3ζ | Lentiviral | T cell | |
| CAR-T-2-M314-2G | Anti-CEA scFv h(CD28-FcεRIγ) CART, pCDCAR1 | Human | BW431/26 | Human | scFv-CD28-FcεRIγ | Lentiviral | T cell | |
| CAR-T-2-M314-2Z | Anti-CEA scFv h(CD28-CD3ζ) CART, pCDCAR1 | Human | BW431/26 | Human | scFv-CD28-CD3ζ | Lentiviral | T cell | |
| CAR-T-2-M314-4G | Anti-CEA scFv h(CD4-FcεRIγ) CART, pCDCAR1 | Human | BW431/26 | Human | scFv-CD4-FcεRIγ | Lentiviral | T cell | |
| CAR-T-2-M314-4Z | Anti-CEA scFv h(CD4-CD3ζ) CART, pCDCAR1 | Human | BW431/26 | Human | scFv-CD4-CD3ζ | Lentiviral | T cell | |
| CAR-T-2-M314-8Z | Anti-CEA scFv h(CD8-CD3ζ) CART, pCDCAR1 | Human | BW431/26 | Human | scFv-CD8-CD3ζ | Lentiviral | T cell | |
| CAR-T-2-M314-BZ | Anti-CEA scFv h(41BB-CD3ζ) CART, pCDCAR1 | Human | BW431/26 | Human | scFv-41BB-CD3ζ | Lentiviral | T cell | |
| CAR-T-2-M314-CZ | Anti-CEA scFv h(b2c-CD3ζ) CART, pCDCAR1 | Human | BW431/26 | Human | scFv-b2c-CD3ζ | Lentiviral | T cell | |
| CAR-T-3-M314-2BZ | Anti-CEA scFv h(CD28-41BB-CD3ζ) CART, pCDCAR1 | Human | BW431/26 | Human | scFv-CD28-41BB-CD3ζ | Lentiviral | T cell | |
| CAR-T-3-M314-2XZ | Anti-CEA scFv h(CD28-OX40-CD3ζ) CART, pCDCAR1 | Human | BW431/26 | Human | scFv-CD28-OX40-CD3ζ | Lentiviral | T cell | |
| CAR-LC019 | Anti-CEA h(CD28-CD3ζ) CAR, pCDCAR1 | Human | Arcitumomab | Mouse | scFv-CD28-CD3ζ | Retroviral | T cell | |
| CAR-LC020 | Anti-CEA h(CD3ζ-CD28) CAR, pCDCAR1 | Human | Labetuzumab | Human | scFv-CD3ζ-CD28 | Retroviral | T cell | |
| CAR-LC368 | Anti-CEACAM5 h(CD3ζ, CD80, 41BBL) Armoured CAR, pCDCAR1 | Human | Arcitumomab | Mouse | scFv-CD3ζ | Lentiviral | T cell | |
| CAR-LC375 | Anti-CEACAM5 h(CD28-CD3ζ, GITR) Armoured CAR, pCDCAR1 | Human | Labetuzumab | Human | scFv-CD28-CD3ζ-GITR | Retroviral | T cell | |
| CAR-MZ042 | Anti-CEA (BW431/26) h(CD3ζ-OX40) CAR, pCDCAR1 | Human | BW431/26 | Human | scFv-CD3ζ-OX40 | Retroviral | T cell | |
| CAR-MZ087 | Anti-CEA (SCA431) h(CD3ζ) CAR, pCDCAR1 | Mouse | SCA431 | Mouse | scFv-CD3ζ | Retroviral | T cell | |
| CAR-MZ088 | Anti-CEA (SCA431) h(CD28-CD3ζ) CAR, Pcdcar1 | Mouse | SCA431 | Mouse | scFv-CD28-CD3ζ | Retroviral | T cell | |
| CAR-MZ089 | Anti-CEA (SCA431) h(OX40-CD3ζ) CAR, pCDCAR1 | Mouse | SCA431 | Mouse | scFv-OX40-CD3ζ | Retroviral | T cell | |
| CAR-MZ090 | Anti-CEA (SCA431) h(CD28-OX40-CD3ζ) CAR, pCDCAR1 | Mouse | SCA431 | Mouse | scFv-CD28-OX40-CD3ζ | Retroviral | T cell | |
| CAR-MZ105 | Anti-CEA (MFE23) h(CD3ζ) CAR, pCDCAR1 | Human | MFE23 | Mouse | scFv-CD3ζ | Retroviral | T cell | |
| CAR-MZ106 | Anti-CEA (MFE23) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | MFE23 | Mouse | scFv-CD28-CD3ζ | Retroviral | T cell | |
| CAR-MZ107 | Anti-CEA (MFE23) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | MFE23 | Mouse | scFv-41BB-CD3ζ | Retroviral | T cell | |
| CAR-MZ108 | Anti-CEA (MFE23) h(CD28-41BB-CD3ζ) CAR, pCDCAR1 | Human | MFE23 | Mouse | scFv-CD28-41BB-CD3ζ | Retroviral | T cell | |
| CAR-MZ144 | Anti-CEA (F11-39) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | F11-39 | Mouse | scFv-CD28-CD3ζ | Lentiviral | T cell | |
| CAR-MZ145 | Anti-CEA (F11-39) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | F11-39 | Mouse | scFv-41BB-CD3ζ | Lentiviral | T cell | |
| CAR-MZ146 | Anti-CEA (F11-39) h(CD28-41BB-CD3ζ) CAR, pCDCAR1 | Human | F11-39 | Mouse | scFv-CD28-41BB-CD3ζ | Lentiviral | T cell | |
| CAR-MZ170 | Anti-CEA (C2-45) h(CD3ζ) CAR, pCDCAR1 | Human | C2-45 | Human | scFv-CD3ζ | Lentiviral | T cell | |
| CAR-MZ171 | Anti-CEA (C2-45) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | C2-45 | Human | scFv-CD28-CD3ζ | Lentiviral | T cell | |
| CAR-MZ172 | Anti-CEA (C2-45) h(CD28-41BB-CD3ζ) CAR, pCDCAR1 | Human | C2-45 | Human | scFv-CD28-41BB-CD3ζ | Lentiviral | T cell | |
| CAR-YF027 | Anti-CEA (C2-45) h(4-1BB-CD3ζ) CAR, pCDCAR1 | Human | C2-45 | Human | scFv-4-1BB-CD3ζ | Lentiviral vector | T cell | |
| CAR-YF028 | Anti-CEA (M5A) h(4-1BB-CD3ζ) CAR, pCDCAR1 | Human | M5A | Human | scFv-4-1BB-CD3ζ | Lentiviral vector | T cell | |
| CAR-YF029 | Anti-CEA (M5A) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | M5A | Human | scFv-CD28-CD3ζ | Lentiviral vector | T cell | |
| CAR-YF030 | Anti-CEA (hMN-14) h(4-1BB-CD3ζ) CAR, pCDCAR1 | Human | hMN-14 | Human | scFv-4-1BB-CD3ζ | Lentiviral vector | T cell | |
| CAR-YF031 | Anti-CEA (hMN-14) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | hMN-14 | Human | scFv-CD28-CD3ζ | Lentiviral vector | T cell | |
| CAR-YF044 | Anti-CEA (CBL-YF010) h(4-1BB-CD3ζ) CAR, pCDCAR1 | Human | CBL-YF010 | Mouse | scFv-4-1BB-CD3ζ | Lentiviral vector | T cell | |
| CAR-YF045 | Anti-CEA (CBL-YF010) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | CBL-YF010 | Mouse | scFv-CD28-CD3ζ | Lentiviral vector | T cell | |
| CAR-YF121 | Anti-CEA (CBL-YF040) h(4-1BB-CD3ζ) CAR, pCDCAR1 | Human | CBL-YF040 | Mouse | scFv-4-1BB-CD3ζ | Lentiviral vector | T cell | |
| CAR-YF149 | Anti-CEA (G4S) h(4-1BB-CD3ζ) CAR, pCDCAR1 | Human | G4S | Mouse | scFv-4-1BB-CD3ζ | Lentiviral vector | T cell |
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