CD276

CD276 (Cluster of Differentiation 276) also know as B7-H3, is a human protein encoded by the CD276 gene. B7-H3 (CD276) is an important immune checkpoint member of the B7 and CD28 families. Induced on antigen-presenting cells, B7-H3 plays an important role in the inhibition of T-cell function. Importantly, B7-H3 is highly overexpressed on a wide range of human solid cancers and often correlates with both negative prognosis and poor clinical outcome in patients. In a recent proteomic study it has been shown that CD276 is differentially expressed in breast cancer compared to normal breast tissue. Furthermore, other studies indicated that CD276 is predominantly expressed on the vascular endothelial cells of various tumors, including breast cancer.


CAR Vector Products Product list:

Catalog Targeting
Cell Type
Generation Antibody
Clone
Vector
Length
Vector
Type
Vector Design Antibody
Host
Data
sheet
Price
CAR-LC160 T cell Second CD276.6 ~8kb Retroviral scFv-CD28-CD3ζ Human Inquiry
CAR-LC161 T cell Second CD276.1 ~8kb Retroviral scFv-CD28-CD3ζ Human Inquiry
CAR-LC162 T cell Second CD276.17 ~8kb Retroviral scFv-CD28-CD3ζ Human Inquiry
CAR-T-1-L334-2 T cell First m851 8kb Lentiviral scFv-CD28 Human Inquiry
CAR-T-1-L334-G T cell First m851 8kb Lentiviral scFv-FcεRIγ Human Inquiry
CAR-T-1-L334-Z T cell First m851 8kb Lentiviral scFv-CD3ζ Human Inquiry
CAR-T-2-L334-2G T cell Second m851 8kb Lentiviral scFv-CD28-FcεRIγ Human Inquiry
CAR-T-2-L334-2Z T cell Second m851 8kb Lentiviral scFv-CD28-CD3ζ Human Inquiry
CAR-T-2-L334-4G T cell Second m851 8kb Lentiviral scFv-CD4-FcεRIγ Human Inquiry
CAR-T-2-L334-4Z T cell Second m851 8kb Lentiviral scFv-CD4-CD3ζ Human Inquiry
CAR-T-2-L334-8Z T cell Second m851 8kb Lentiviral scFv-CD8-CD3ζ Human Inquiry
CAR-T-2-L334-BZ T cell Second m851 8kb Lentiviral scFv-41BB-CD3ζ Human Inquiry
CAR-T-2-L334-CZ T cell Second m851 8kb Lentiviral scFv-b2c-CD3ζ Human Inquiry
CAR-T-3-L334-2BZ T cell Third m851 8kb Lentiviral scFv-CD28-41BB-CD3ζ Human Inquiry
CAR-T-3-L334-2XZ T cell Third m851 8kb Lentiviral scFv-CD28-OX40-CD3ζ Human Inquiry

CAR Viral Particles Product list:

Catalog Antibody
Clone
Packaging
System
Generation Gene
Construct
Promotor Packaging
Cell
Titer Data
sheet
Price
VP-CAR-LC644 CD276.6 Lentivirus Second scFv (CD276.6)-CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC645 CD276.1 Lentivirus Second scFv (CD276.1)-CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC646 CD276.17 Lentivirus Second scFv (CD276.17)-CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC85 m851 Lentivirus First scFv (m851)-CD28 CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC86 m851 Lentivirus First scFv (m851)-FcεRIγ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC87 m851 Lentivirus First scFv (m851)-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC88 m851 Lentivirus Second scFv (m851)-CD28-FcεRIγ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC89 m851 Lentivirus Second scFv (m851)-CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC90 m851 Lentivirus Second scFv (m851)-CD4-FcεRIγ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC91 m851 Lentivirus Second scFv (m851)-CD4-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC92 m851 Lentivirus Second scFv (m851)-CD8-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC93 m851 Lentivirus Second scFv (m851)-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC94 m851 Lentivirus Second scFv (m851)-b2c-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC95 m851 Lentivirus Third scFv (m851)-CD28-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC96 m851 Lentivirus Third scFv (m851)-CD28-OX40-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
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Tel: 44-207-048-3343

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