CD276 (Cluster of Differentiation 276) also know as B7-H3, is a human protein encoded by the CD276 gene. B7-H3 (CD276) is an important immune checkpoint member of the B7 and CD28 families. Induced on antigen-presenting cells, B7-H3 plays an important role in the inhibition of T-cell function. Importantly, B7-H3 is highly overexpressed on a wide range of human solid cancers and often correlates with both negative prognosis and poor clinical outcome in patients. In a recent proteomic study it has been shown that CD276 is differentially expressed in breast cancer compared to normal breast tissue. Furthermore, other studies indicated that CD276 is predominantly expressed on the vascular endothelial cells of various tumors, including breast cancer.

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