The CD4 surface receptor is mainly expressed on distinct populations of thymocytes and mature T-lymphocytes, but also at lower levels on macrophages, monocytes, and dendritic cells. CD4 is an integral membrane glycoprotein of approximately 58 kDa that contains four extracellular domains showing sequence and structural homologies with members of the immunoglobulin superfamily. The function of CD4 in the antigen presentation process is to contact nonpolymorphic regions of the MHC-II molecules expressed at the surface of APC. CD4 acts as an adhesion molecule that stabilizes the interaction between the TCR and MHC-II molecules loaded with antigenic peptides, but it also participates in signal-transduction pathways. CD4 could be a receptor for the lymphocyte chemotactic factor IL-16 and the secreted gp17 glycoprotein. In addition to its physiological functions, CD4 serves as the primary surface receptor for the HIV. Binding of the viral envelope glycoprotein gp120 to CD4 mediates attachment of the HIV particle, which then enters the cell through subsequent interactions with other non-CD4 cellular receptors.
|CAR-MZ248||T cell||Second||~8kb||Retroviral||CD4-10-gp120 scFv-CD28-CD3ζ||Inquiry|
|CAR-MZ249||T cell||Second||~8kb||Retroviral||CD4-35-gp120 scFv-CD28-CD3ζ||Inquiry|
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