Human Genotyping Services
HLA Typing Service
Our high-resolution HLA typing service utilizes advanced NGS-based platforms to analyze the highly polymorphic Human Leukocyte Antigen (HLA) system. We offer comprehensive typing for HLA-A, B, C, G, DRB1, DRB3, DRB4, DRB5, DQA1, DQB1, DPA1, and DPB1, providing precise results critical for disease defense research, cancer protection studies, and organ transplant compatibility assessment. Our streamlined workflow ensures fast, accurate, and cost-effective solutions for your HLA typing needs.
HLA Testing Services
Creative Biolabs provides a full spectrum of HLA testing services beyond genotyping, including HLA antibody detection, non-HLA antibody detection, HLA blocking assays, neutralizing assays, and competition assays. These services are essential for identifying HLA genes and antigens in alloimmunization episodes, assessing sensitization status, and evaluating transplant compatibility. Our comprehensive testing helps prevent adverse immunologic effects in transfusion therapy and transplantation.
KIR Typing Service
Our KIR typing service enables comprehensive analysis of Killer-cell Immunoglobulin-like Receptors (KIRs), which are crucial for NK cell function in the innate immune system. We detect all 15 human KIR genes and their alleles at both genomic DNA and transcriptomic mRNA levels. Using our advanced High-Throughput Sequencing platform, we determine copy numbers and provide high-resolution genotypes, supporting research in cancer immunotherapy and transplantation.
Animal MHC Genotyping Services
Rhesus Macaque MHC Genotyping Service
Our specialized service for rhesus macaque (Mamu) MHC genotyping employs targeted NGS technologies to identify polymorphisms in Mamu-A, Mamu-B, Mamu-E, Mamu-F, and Mamu-G genes. This service is essential for experimental allograft studies, stem cell research, and understanding biological parameters in this important primate model. Our user-friendly computational applications ensure reliable genotyping results from both DNA and RNA samples.
Mouse H2 Genotyping Service
Creative Biolabs offers comprehensive H2 complex genotyping for mice, analyzing both class I and class II genes critical to immune function. Our NGS-based service provides high-resolution genotyping of the mouse MHC located on chromosome 17, supporting various immunological studies. We ensure stringent quality control and offer multiple genotyping approaches to meet diverse research requirements.
Rat RT1 Genotyping Service
Our RT1 genotyping service targets the rat MHC complex, analyzing both classical and non-classical molecules across the 4 Mb RT1 region. This service is particularly valuable for transplantation research and experimental autoimmune disease studies. We provide comprehensive analysis of RT1-A region genes and nonclassical molecules, delivering accurate results within days through our optimized workflow.
Rabbit RLA Genotyping Service
We offer specialized genotyping services for rabbit leukocyte antigen (RLA), covering class I, II, and III genes homologous to human HLA. Our NGS-based approach identifies the complexity of RLA polymorphisms and has defined 13 haplotypes based on RFLP analysis. This service includes high-performance DNA/RNA extraction and purification, with automated workflows that increase efficiency and throughput.
Dog DLA Genotyping Service
Our dog leukocyte antigen (DLA) genotyping service focuses on identifying DLA polymorphisms associated with canine immune diseases such as hemolytic anemia, thyroiditis, and immune polyarthritis. We analyze the DLA genomic regions on chromosome 12, including class I genes (DLA-88, DLA-12, DLA-64) and class II genes (DLA-DR, DLA-DQ, DLA-DM, DLA-DO), providing valuable data for regenerative medicine research.
Guinea Pig GPLA Genotyping Service
Creative Biolabs provides comprehensive guinea pig leucocyte antigen (GPLA) genotyping, analyzing both class I antigens (B1, BL, B3, B4) and class II associated antigens (Ia). Our NGS-based service offers pre-validated genotyping panels and high-resolution results, supporting research in this unique model where most T cells express Ia antigens, unlike mice or humans.
