Creative Biolabs has a tradition of commitment. To achieve efficient execution and regulatory approval, we offer careful considerations of your program for the development of a cellular or gene therapy product – now and in the future.
EXPLORE MORE HighlightsWe focus on unmet needs and develop novel cellular and gene drugs and solutions that offer significant benefits over existing options.
EXPLORE MORE HighlightsThe advent of Chimeric Antigen Receptor T-cell (CAR-T) therapies has revolutionized the field of oncology, providing new avenues for treating various forms of cancer. Our 20 years of experience in the biotechnology sector have equipped us with the expertise and technological capabilities to support the entire lifecycle of CAR-T products, from early development to commercialization.
EXPLORE MORETo accelerate advanced breakthroughs of your projects, we offer broad range of platforms which enable our clients be free to tackle problems with cutting-edge technologies from different angles and in different methods.
EXPLORE MORE HighlightsUse the resources in our library to help you understand your options and make critical decisions for your study. We offer oncolytic virus, CAR-T, and dendritic cell related documents, as well as newsletter. If you don't find the answers you're looking for, contact us for additional assistance.
EXPLORE MORE HighlightsGet a real taste and understanding of the business and culture of one of the world's great research-based cellular and gene therapy discovery and development companies.
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The therapeutic promise of CAR-T cells extends beyond basic antigen recognition—functional robustness is key. However, many constructs exhibit variability in activation thresholds, persistence, cytotoxicity, or are prone to exhaustion and immune suppression in preclinical models. Studies highlight that precise tuning of T cell function—rather than relying solely on genetic modification—can significantly enhance performance across disease models.
Fig.1 Functional parameters on activated CAR T cells.1
At Creative Biolabs, our Comprehensive Functional CAR-T Optimization Services are designed to meet the rapidly evolving needs of preclinical discovery. Through integrated optimization of CAR constructs, immune cell behavior, and tumor model adaptation, we offer tailored solutions to improve CAR-T efficacy, specificity, and durability in both in vitro and in vivo research settings.
This service suite enables biotech and academic partners to interrogate and enhance CAR-T cell functionality across seven critical biological axes. Each module is engineered to address key preclinical challenges—from activation dynamics to TME resilience—supported by advanced analytics and customized engineering platforms.
CAR-T Cell Activation and Expansion Profile Optimization Service
We optimize intracellular signaling domains and culture conditions to fine-tune CAR-T activation kinetics and sustained proliferation. Our approaches minimize tonic signaling and premature exhaustion to improve downstream function.
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CAR-T Cell Tumor Cytotoxicity Enhancement Service
Through co-culture assays and phenotypic screening, we assess and enhance the direct tumor-killing capacity of CAR-T cells. Effector potency is validated using both adherent and suspension tumor cell lines under diverse conditions.
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CAR-T Cell Cytokine Release Profile Modulation Service
We fine-tune cytokine expression using synthetic biology tools and promoter engineering to control inflammatory cascades (e.g., IL-2, IFN-γ), supporting safer and more targeted immune activity in vitro and in vivo.
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CAR-T Cell and Immune Cell Interaction Enhancement Service
We characterize CAR-T interactions with NK cells, dendritic cells, and suppressive T cell subsets to identify crosstalk bottlenecks. Modulation strategies include checkpoint editing and accessory ligand optimization.
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CAR-T Cell In Vivo Anti-Tumor Activity Enhancement Service
Our humanized and immunocompromised mouse models allow for comprehensive in vivo evaluation of CAR-T cell distribution, tumor control, and persistence—providing function-driven guidance for construct selection.
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CAR-T Cell Tumor Microenvironment Activity Enhancement Service
We apply genome editing and co-stimulation tuning to help CAR-T cells overcome suppressive features such as TGF-β, hypoxia, and metabolic competition. Functional resilience is measured under stress-mimicking co-culture systems.
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scFv Optimization Service for Functional CAR-T Optimization
Using phage display, computational modeling, and epitope engineering, we enhance the binding specificity, affinity, and stability of the scFv module—supporting optimal signaling thresholds and minimal off-target activity.
TME-Adaptive Functional Testing Platforms
We offer validated 3D tumor spheroids, ECM-rich matrices, and hypoxia chambers to mimic the complexity of the tumor microenvironment—providing more accurate readouts for CAR-T cell performance under suppressive conditions.
scFv Customization Built-In
Leveraging our proprietary antibody engineering pipeline, we support the direct refinement of scFvs for CAR-T applications, bridging binder selection with functional validation for a streamlined workflow.
Deep Functional Profiling Tools
From single-cell cytokine capture assays to multiplexed imaging and flow cytometry, our functional assays reveal subtle changes in T cell behavior that standard viability screens often miss.
Interdisciplinary Expert Support
Our team comprises specialists in molecular immunology, cell engineering, and tumor modeling. This enables end-to-end technical consultation tailored to your CAR construct's biological context.
Flexible and Modular Collaboration Models
Whether you're seeking a full-stack optimization campaign or a targeted assay to validate a single construct, we offer flexible work packages to match your R&D scope and timeline.
Whether you're refining a lead construct or comparing multiple candidates in parallel, Creative Biolabs delivers high-resolution functional insights that accelerate CAR-T discovery. Our dedicated scientific team is ready to support your program with customized, data-driven strategies.
Contact us today to schedule a consultation or request a service quote—we look forward to being your trusted preclinical partner in CAR-T innovation.
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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.
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