Efficient & High-Quality Immunoadhesin Production Service

Creative Biolabs provides an effective and high-quality immunoadhesin production service to accelerate worldwide research and development, so that addressing issues in obtaining high-quality immunoadhesins for research or therapeutic development.

The Necessity of Efficient and High-Quality Immunoadhesin Production

Immunoadhesins have great potential across fundamental research, disease diagnostics, and treatment development by combining the binding specificity of an antibody's variable region with the effector capabilities of an immunoglobulin's constant region. Historically generated in mammalian cell culture systems such as CHO cells, which provide the benefit of human-like glycosylation essential for function, this approach may be time-consuming and expensive. A possibly scalable and reasonably affordable approach is plant-based expression systems. Therefore, speeding research and development depends on the development of effective and high-quality immunoadhesin manufacturing techniques, which guarantee more reasonably priced access to these important proteins for both research and therapeutic uses.

Fig.1 Design and generation of an Ig-adhesins.¹

Efficient and High-Quality Immunoadhesin Production Service at Creative Biolabs

Creative Biolabs offers an efficient and high-quality immunoadhesin production service to empower your research and therapeutic development. Our advanced platforms enable the rapid generation of high-quality immunoadhesins, innovative molecules engineered to target pathogens with exceptional specificity. By fusing the binding domains of human receptors with the potent effector regions of antibodies, these immunoadhesins act as molecular decoys, effectively neutralizing viruses and bacterial toxins by preventing their interaction with host cells. At Creative Biolabs, we provide the capacity for large-scale, reliable production, ensuring a consistent supply of these crucial tools to advance your efforts in combating infectious diseases.

Our Workflow

Available Expression System at Creative Biolabs

A high yield, adequate protein folding, and suitable post-translational modifications—especially glycosylation, which may dramatically affect immunoadhesin activity and immunogenicity—all depend on the host cell choice. Common expression systems include:

• Mammalian cells: CHO cell, HEK293 cell
• Plant-based expression system: Nicotiana benthamiana
• Other systems: insect cell, yeast system

Required Starting Materials

We need customers to provide the information listed below to start the project:

• Target antigen sequence
• Desired immunoadhesin format (e.g., IgG-Fc fusion)
• Specific functional requirements (if any)

Attractive Advantages

• High Purity

Our optimized purification process ensures that you receive immunoadhesins of the highest purity.

• Customizable Solutions

We tailor our service to meet your specific project requirements, including expression system selection and purification strategies.

• Fast Turnaround Times

We employ efficient workflows to deliver your immunoadhesins in a timely manner.

• Scalability

We offer production scales to support your research needs, from small-scale to large-scale production.

FAQs

For more information about our efficient and high-quality immunoadhesin production service and how we can assist your project, please contact us directly.

Reference

1. Pincus, Seth H., et al. "Bispecific anti-HIV immunoadhesins that bind Gp120 and Gp41 have broad and potent HIV-neutralizing activity." Vaccines 9.7 (2021): 774. Distributed under Open Access License CC BY 4.0, without modification.