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Cytokine-induced killer (CIK) cell therapy represents a promising approach to cancer immunotherapy. CIK cells are a heterogeneous population comprising T cells, T-natural killer (NK) cells, and a minor fraction of NK cells that exhibit potent cytotoxic activity against tumor cells. They are characterized by their ability to mediate both T cell receptor-dependent and MHC-independent tumor cytotoxicity, which enhances their effectiveness across a diverse range of cancer types.
The therapeutic potential of CIK cells is underscored by their efficient and rapid expansion capabilities in culture, which allows for scalable manufacturing tailored to individual patient needs. Their mechanism of action involves a robust cytotoxic response through various pathways, including NKG2D, TRAIL, FasL, and DNAM-1, among others. This diversity in action mechanisms provides a compelling rationale for their use in combating relapse post-allogeneic hematopoietic stem cell transplantation in patients with hematological malignancies.
Fig.1 Mechanism of tumor recognition and anticancer activity of CIK cells.1
At Creative Biolabs, we leverage our 20 years of expertise to offer advanced solutions for developing CIK cell therapy. Our approach is holistic, combining cutting-edge research with comprehensive service offerings that cater to the specific needs of our clients dealing with various cancer types.
Our services are underpinned by a robust understanding of the immunological underpinnings and clinical applications of CIK cells, enabling us to navigate and mitigate challenges in immunotherapy development effectively. By maintaining stringent adherence to good manufacturing practices (GMP)-compliant standards, we ensure that every therapeutic product or solution delivered is of the highest quality and efficacy.
Creative Biolabs offers a full suite of services to facilitate the development of CIK therapies from concept to clinical application. Our offerings include:
CellRapeutics™ One-Stop CIK Therapy Development Services
Creative Biolabs provides one-stop services that cover every aspect of CIK cell therapy development. This includes the bespoke expansion protocols for CIK cells tailored to specific tumor types, ensuring optimal yield and potency. Our specialty lies in enhancing the specificity of CIK cells via genetic engineering and surface marker targeting, thus significantly reducing off-target effects and maximizing therapeutic outcomes.
CellRapeutics™ CIK Therapy Improvement Services
A cornerstone of our services is the improvement of CIK therapy through incorporating targeted strategies to enhance the efficacy of Cytokine-Induced Killer (CIK) cell therapy, combining CIK cells with other immunotherapies strategies, such as CAR-CIK development, DC-CIK development, dendritic cells (DCs), CIK combined with chemotherapy/radiotherapy development.
Partnering with Creative Biolabs offers numerous advantages:
Q1. Why choose CIK therapy over other immunotherapies?
A1: CIK therapy provides a unique combination of T and NK cell functionalities, enabling non-MHC-restricted cytotoxic activities which are crucial for targeting diverse tumor cells.
Q2. Can CIK cells be used for solid tumors as well as hematological malignancies?
A2: Yes, CIK cells have shown efficacy in both solid tumors and blood cancers, effectively targeting even chemo-resistant cancer stem cells, thereby broadening their therapeutic impact.
By providing these scientifically robust and operationally efficient CIK therapy development solutions, Creative Biolabs stands at the forefront of cancer immunotherapy innovation, empowering solutions that extend beyond the laboratory to impactful clinical applications.
Reference
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