DNA-based Artificial T Cell-Stimulating Platform Development Service

Overview

T cells are central players in both immune system function and the success of immunotherapies. Manipulating T cell populations, particularly expanding specific T cell subtypes, is a key strategy for enhancing immunotherapy effectiveness. Natural T cell activation is a tightly regulated process, relying on intricate interactions between T cells and antigen-presenting cells to initiate an immune response. To enhance cell therapies and directly activate T cells for off-the-shelf treatments, scientists have been working on artificial platforms that can mimic this natural stimulation process. Amongst, the advancements in DNA nanotechnology and biomaterials are expanding the toolkit for precise and targeted immune activation, offering new possibilities for cancer immunotherapy and other cell-based therapies.

Fig.1 Biomaterials boost CAR-T efficacy in solid tumors.¹

DNA-based Artificial T Cell-Stimulating Platform Development Service at Creative Biolabs

Creative Biolabs integrates advanced DAN nanotechnology and biomaterials to establish a DNA-based artificial T cell stimulating platform development service. This innovative platform utilizes DNA-based scaffolds to create long dendritic cell-like processes, maximizing the surface area-to-volume ratio for optimal T cell stimulation. The platform can be customized with various protein conjugation chemistries to precisely control the conjugation of multiple distinct proteins at controlled ratios. This allows for fine-tuning of T cell activation signals and improved antibody conjugation. With our extensive expertise and experience, Creative Biolabs guarantees the development of a highly effective and customizable T cell stimulating platform tailored to your specific research needs.

Moreover, Creative Biolabs provides comprehensive functional characterization services, which span the entire development process, from in vitro characterization of the artificial T cell stimulator/stimulating platform toin vivo evaluation of its efficacy. Utilizing cutting-edge technologies, we ensure high-quality results while closely monitoring every step. At Creative Biolabs, we are committed to delivering satisfactory results within the customer's desired timeframe, empowering our customers to develop more effective and durable cancer T cell therapies.

Benefits for You

Associated Services

In addition to artificial T cell stimulation platforms developed based on DNA technology, we are also able to harness the potential of various advanced materials, including nanoparticles, metal particles, cells, and hydrogel biocompatible materials. This allows us to develop highly effective and customizable platforms tailored to your specific research needs. Our expertise in multiple technologies provides a variety of options for customized development, ensuring the optimal solution for your T cell stimulation research.

• Artificial T cell Stimulator Development Services
• Hydrogel-based Artificial T Cell-Stimulating Platform Development Services
• Alternative Polymeric-based Artificial T Cell-Stimulating Platform Development Service
• Soluble T Cell-Stimulating Platform Development Service

For researchers seeking a cutting-edge, custom-designed DNA-based platform to optimize artificial T cell stimulation, Creative Biolabs offers expert consultation and development services. If you'd like to learn more about building and developing a premium DNA-based platform for artificial T cell stimulation suited to your unique needs, please contact us for more details.

Reference

1. Qin, Ya-Ting, et al. "Biomaterials promote in vivo generation and immunotherapy of CAR-T cells." Frontiers in Immunology 14 (2023): 1165576. Distributed under Open Access License CC BY 4.0, without modification.