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TOP2A

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

TOP2A is a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
CAR-YC0805 Anti-TOP2A (CBYCD-523) h(scFv-41BB-CD3ζ) CAR, pCDCAR1 Human CBYCD-523 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YC1705 Anti-TOP2A (CBYCD-523) h(scFv-CD28-CD3ζ) CAR, pCDCAR1 Human CBYCD-523 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ304 Anti-TOP2A (19D4) h(41BB-CD3ζ) CAR, pCDCAR1 Human 19D4 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ305 Anti-TOP2A (1B10) h(41BB-CD3ζ) CAR, pCDCAR1 Human 1B10 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ306 Anti-TOP2A (1C5) h(41BB-CD3ζ) CAR, pCDCAR1 Human 1C5 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ307 Anti-TOP2A (1D2) h(41BB-CD3ζ) CAR, pCDCAR1 Human 1D2 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ308 Anti-TOP2A (1D5) h(41BB-CD3ζ) CAR, pCDCAR1 Human 1D5 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ309 Anti-TOP2A (2A9) h(41BB-CD3ζ) CAR, pCDCAR1 Human 2A9 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ310 Anti-TOP2A (2D12) h(41BB-CD3ζ) CAR, pCDCAR1 Human 2D12 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ311 Anti-TOP2A (2F8) h(41BB-CD3ζ) CAR, pCDCAR1 Human 2F8 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ312 Anti-TOP2A (548CT6.1.1) h(41BB-CD3ζ) CAR, pCDCAR1 Human 548CT6.1.1 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ313 Anti-TOP2A (8D2) h(41BB-CD3ζ) CAR, pCDCAR1 Human 8D2 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ314 Anti-TOP2A (Ki-S1) h(41BB-CD3ζ) CAR, pCDCAR1 Human Ki-S1 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ315 Anti-TOP2A (TOP2A/1362) h(41BB-CD3ζ) CAR, pCDCAR1 Human TOP2A/1362 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ316 Anti-TOP2A (TPM2A-1) h(41BB-CD3ζ) CAR, pCDCAR1 Human TPM2A-1 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ317 Anti-TOP2A (TPM2A-2) h(41BB-CD3ζ) CAR, pCDCAR1 Human TPM2A-2 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ318 Anti-TOP2A (TOP2A/1361) h(41BB-CD3ζ) CAR, pCDCAR1 Human, Mouse TOP2A/1361 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ804 Anti-TOP2A (19D4) h(CD28-CD3ζ) CAR, pCDCAR1 Human 19D4 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ805 Anti-TOP2A (1B10) h(CD28-CD3ζ) CAR, pCDCAR1 Human 1B10 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ806 Anti-TOP2A (1C5) h(CD28-CD3ζ) CAR, pCDCAR1 Human 1C5 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
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