ALK

Anaplastic lymphoma kinase (ALK) also known as ALK tyrosine kinase receptor or CD246, is an enzyme that in humans is encoded by the ALK gene. ALK is a membrane associated tyrosine kinase receptor of the insulin receptor superfamily. The function of the full-length ALK receptor is poorly understood. It has a probable role in the central and peripheral nervous system development and maintenance. ALK is a dependence receptor, which may exert antagonist functions, proapoptotic or antiapoptotic, depending on the absence or presence of a ligand. Dependence receptors have a potential role in cancer and development. The EML4-ALK fusion gene is responsible for approximately 3-5% of non-small-cell lung cancer(NSCLC) and this gene product was designed for the treatment of NSCLC.

Associated Disease
  • Non-small cell lung cancer (NSCLC)
  • Anaplastic large cell lymphoma (ALCL)
  • Diffuse large B-cell lymphoma (DLBCL)
  • Lung malignancy

CAR Vector Products Product list:

Catalog Targeting
Cell Type
Generation Antibody
Clone
Vector
Length
Vector
Type
Vector Design Antibody
Host
Data
sheet
Price
CAR-LC101 T cell Second ALK15 ~8kb Retroviral scFv-CD28-CD3ζ Mouse Inquiry
CAR-LC102 T cell Second ALK15 ~8kb Retroviral scFv-41BB-CD3ζ Mouse Inquiry
CAR-LC103 T cell Third ALK15 ~8kb Retroviral scFv-CD28-41BB-CD3ζ Mouse Inquiry
CAR-LC104 T cell Second hALK15SH ~8kb Retroviral scFv-CD28-CD3ζ Human Inquiry
CAR-LC105 T cell Second hALK15SH ~8kb Retroviral scFv-41BB-CD3ζ Human Inquiry
CAR-LC106 T cell Third hALK15SH ~8kb Retroviral scFv-CD28-41BB-CD3ζ Human Inquiry
CAR-LC107 T cell Second ALK48 ~8kb Retroviral scFv-CD28-CD3ζ Mouse Inquiry
CAR-LC108 T cell Second ALK48 ~8kb Retroviral scFv-41BB-CD3ζ Mouse Inquiry
CAR-LC109 T cell Third ALK48 ~8kb Retroviral scFv-CD28-41BB-CD3ζ Mouse Inquiry
CAR-LC110 T cell Second hALK48SH ~8kb Retroviral scFv-CD28-CD3ζ Human Inquiry
CAR-LC111 T cell Second hALK48SH ~8kb Retroviral scFv-41BB-CD3ζ Human Inquiry
CAR-LC112 T cell Third hALK48SH ~8kb Retroviral scFv-CD28-41BB-CD3ζ Human Inquiry
CAR-LC113 T cell Second ALK53 ~8kb Retroviral scFv-CD28-CD3ζ Mouse Inquiry
CAR-LC114 T cell Second ALK53 ~8kb Retroviral scFv-41BB-CD3ζ Mouse Inquiry
CAR-LC115 T cell Third ALK53 ~8kb Retroviral scFv-CD28-41BB-CD3ζ Mouse Inquiry
CAR-LC116 T cell Second hALK53 ~8kb Retroviral scFv-CD28-CD3ζ Human Inquiry
CAR-LC117 T cell Second hALK53 ~8kb Retroviral scFv-41BB-CD3ζ Human Inquiry
CAR-LC118 T cell Third hALK53 ~8kb Retroviral scFv-CD28-41BB-CD3ζ Human Inquiry
CAR-LC119 T cell Second ALK58 ~8kb Retroviral scFv-CD28-CD3ζ Mouse Inquiry
CAR-LC120 T cell Second ALK58 ~8kb Retroviral scFv-41BB-CD3ζ Mouse Inquiry
CAR-LC121 T cell Third ALK58 ~8kb Retroviral scFv-CD28-41BB-CD3ζ Mouse Inquiry
CAR-LC122 T cell Second hALK58 ~8kb Retroviral scFv-CD28-CD3ζ Human Inquiry
CAR-LC123 T cell Second hALK58 ~8kb Retroviral scFv-41BB-CD3ζ Human Inquiry
CAR-LC124 T cell Third hALK58 ~8kb Retroviral scFv-CD28-41BB-CD3ζ Human Inquiry

CAR Viral Particles Product list:

Catalog Antibody
Clone
Packaging
System
Generation Gene
Construct
Promotor Packaging
Cell
Titer Data
sheet
Price
VP-CAR-LC589 ALK15 Lentivirus Second scFv (ALK15)-CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC590 ALK15 Lentivirus Second scFv (ALK15)-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC591 ALK15 Lentivirus Third scFv (ALK15)-CD28-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC592 hALK15SH Lentivirus Second scFv (hALK15SH)-CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC593 hALK15SH Lentivirus Second scFv (hALK15SH)-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC594 hALK15SH Lentivirus Third scFv (hALK15SH)-CD28-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC595 ALK48 Lentivirus Second scFv (ALK48)-CD28-CD3ζ CMV 293T A Inquiry
VP-CAR-LC596 ALK48 Lentivirus Second scFv (ALK48)-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC597 ALK48 Lentivirus Third scFv (ALK48)-CD28-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC598 hALK48SH Lentivirus Second scFv (hALK48SH)-CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC599 hALK48SH Lentivirus Second scFv (hALK48SH)-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC600 hALK48SH Lentivirus Third scFv (hALK48SH)-CD28-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC601 ALK53 Lentivirus Second scFv (ALK53)-CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC602 ALK53 Lentivirus Second scFv (ALK53)-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC603 ALK53 Lentivirus Third scFv (ALK53)-CD28-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC604 hALK53 Lentivirus Second scFv (hALK53)-CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC605 hALK53 Lentivirus Second scFv (hALK53)-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC606 hALK53 Lentivirus Third scFv (hALK53)-CD28-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC607 ALK58 Lentivirus Second scFv (ALK58)-CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC608 ALK58 Lentivirus Second scFv (ALK58)-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC609 ALK58 Lentivirus Third scFv (ALK58)-CD28-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC610 hALK58 Lentivirus Second scFv (hALK58)-CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC611 hALK58 Lentivirus Second scFv (hALK58)-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC612 hALK58 Lentivirus Third scFv (hALK58)-CD28-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
CONTACT US

USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

Europe
Ringstrasse 4, 64401 Gross-Bieberau, Germany
Tel: 44-207-048-3343

Distributors

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Australia
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