The vector of anti-ALK chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human ALK. The T cells are genetically modified through transduction with a retroviral vector expressing scFv of anti-ALK3 antibody linked to CD28, 4-1BB (CD137) and CD3ζ signaling domains. And the vector product was designed for the treatment of non-small cell lung cancer (NSCLC).
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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