A successful biomarker analysis program requires scientific expertise, up-to-date regulatory knowledge, and operational excellence. Creative Biolabs has extensive experience in performing method development, validation, and sample analysis in a regulated environment. Creative Biolabs is a partner you can trust to deliver on your biomarker program every time.
Background
ABCA1, an ATP-binding cassette transporter A1, mediates cholesterol efflux to lipid-poor high-density lipoprotein (HDL) apolipoproteins and plays an important role in the elimination of cholesterol from macrophage-derived foam cells in the artery wall. Modulation of ABCA1 expression in macrophages constitutes a therapeutic target for the prevention of human atherosclerosis.
Fig.1 ABCA1 functions in different cell types and associated diseases.1
Involvement in disease
- Tangier disease (TD) is caused by mutations in ABCA1 gene.
- Defects in ABCA1 are also a cause of high density lipoprotein deficiency type 2 (HDLD2).
- ABCA1 has also been implicated in regulating cholesterol homeostasis and insulin secretion in pancreatic β cells.
- Several polymorphisms and mutations in ABCA1 have been associated with type 2 diabetes (T2DM) in multiple ethnic groups.
Increase Your Chance for Paramount Discoveries
Our understanding of the role and function of ABCA1 has evolved from the traditional function in maintaining cellular cholesterol homeostasis to include its potent anti-inflammatory function. Nowadays, growing evidence has clearly implicated ABCA1 as a target of interest in diseases typified by inflammation. This has led to the possibility of exploiting known and novel signaling pathways to upregulate ABCA1 expression in several chronic disease settings. Creative Biolabs complements our exceptional scientific expertise with state-of-the art technologies to offer our customer flexible ABCA1 analysis services.
| Cat | Service |
| BAS69-1 | ABCA1 Mutations Detection Service |
| BAS69-2 | ABCA1 Protein Expression Analysis |
| BAS69-3 | Confocal Microscopy |
| BAS69-4 | Cell Surface Biotinylating Assay |
| BAS69-5 | Cholesterol efflux assay |
| BAS69-6 | ABCA1 Knockdown Assay |
| BAS69-7 | Transendothelial Electrical Resistance Measurement |
Integrated Solutions
- ABCA1 Mutations Detection
- ABCA1 Protein Expression Analysis
- ELISA/WB/IHC/IP…
- Confocal Microscopy
- Fluorescent confocal microscopy analysis of candidate on ABCA1 localization.
- Cell Surface Biotinylation Assay
- ABCA1 localization measurement
- Cholesterol Efflux Assay
- ABCA1 Knockdown Assay
- Transendothelial Electrical Resistance Measurement
Our wide variety of technology platforms allow Creative Biolabs to choose the right technology for your biomarker. No matter how complex the assay, our team has the scientific and regulatory expertise to measure your biomarker and to ensure delivery of quality results on time. Please don't hesitate to contact us today to develop custom solution for specific needs. We will work to accommodate your request.
Reference
- Jacobo-Albavera, Leonor, et al. "The role of the ATP-binding cassette A1 (ABCA1) in human disease." International Journal of Molecular Sciences 22.4 (2021): 1593. Distributed under Open Access license CC BY 4.0, without modification.
For Research Use Only.
