Beta-actin (ACTB), a highly conserved cytoskeleton structural protein, has been regarded as a common housekeep gene and used as a reference gene for years. However, accumulating evidence indicates that ACTB is abnormally expressed in multiple cancers and hence changes the cytoskeleton to affect the invasiveness and metastasis of tumors. As a leader in the field of biological assays, Creative Biolabs is committed to providing our clients around the world with the most convenient and accurate ACTB analysis services.
ACTB, a highly conserved cytoskeletal protein, is widely distributed in all eukaryotic cells. Differential expression of ACTB was found between cancer and adjacent normal tissues, and significant associations was found between ACTB expression and prognosis of tumor patients. Studies revealed a significant correlation between preclinical altered ACTB methylation in blood and stroke and suggested the potential of blood-based ACTB methylation for the early detection and even prevention of stroke. Besides, anti-ACTB antibodies may be a potential biomarker of ALS could indicate disease severity.
The ACTB gene, a well-known housekeeping gene, has been widely used to normalize the expression of genes in cell lines and in variant human tissue samples. As for protein level, anti-ACTB antibodies have been used for immunofluorescence to visualize the cytoskeleton of cuttlefish skin cells as they undergo rapid changes in structure and shape.
Nowadays, Creative Biolabs offers ACTB reagents for your research needs including: ACTB antibodies, ACTB lysates, ACTB proteins and ACTB RNAi. Our antibody can recognize both native and denatured forms of ACTB. Our services include but not limited to the following:
1. MALDI-TOF Mass Spectrometry
MALDI-TOF mass spectrometry was used to determine the levels of DNA methylation quantitatively.
2. ACTB Expression Analysis
3. Genetic Alteration Analysis
4. Functional Studies of ACTB mutation
5. Exome Sequence Analysis
6. Knockdown Analyses of AGR2
7. Anti-ACTB Antibody Detection
Serum anti-ACTB antibody levels could be detected using the amplified luminescent proximity homogeneous assay-linked immunosorbent assay.
| Cat | Service |
| BAS72-1 | MALDI-TOF Mass Spectrometry |
| BAS72-2 | ACTB Expression Analysis |
| BAS72-3 | ACTB Genetic Alteration Analysis |
| BAS72-4 | Functional Studies of ACTB Mutation |
| BAS72-5 | Exome Sequence Analysis |
| BAS72-6 | Knockdown Analyses of ACTB |
| BAS72-7 | Anti-ACTB Antibody Detection |
Biomarker studies encompass detection of disease-specific analytes of interest utilizing a variety of methods such as multiplex protein analysis, WB, ELISA, qPCR, FACS, IHC/ISH and so forth.
Creative Biolabs is competent to achieve professional and first-class biomarker analysis by using validated approaches and cutting-edge technologies. In addition to the above services, we can also design, improve, or develop new analysis solutions according to your research direction. If we can improve your project in any way or you have any further demands, please don't hesitate to contact us.
For Research Use Only.