Activin receptor type 2A (ACVR2A), a receptor for the cell signaling protein activin A, can act as a solid diagnostic biomarker and provide insights into the mechanism underlying the unique clinical characteristics. Headed by globally-recognized key opinion leaders, Creative Biolabs has exceptional experience in development and validation of biomarker assays to meet the needs of each specific context of use. We now provide customized ACVR2A analysis services for worldwide customers.
Background
ACVR2A is a type II member of the TGF-beta family of receptor Serine/Threonine kinases. It is involved in the activin and myostatin signaling pathway. ACVR2A is located on chromosome 2 and comprises 11 exons. It contains two eight polyadenine DNA microsatellite sites in exon 3 and exon 10, which makes it highly predisposed to mutation.
The ACVR2A protein is a transmembrane receptor that is divided into an extracellular receptor region, a transmembrane region, and an intracellular kinase region. The binding of activin to ACVR2A leads to the phosphorylation of downstream Smad and non-Smad signal transduction proteins. The truncating mutations occurring in ACVR2A exon 3 and exon 10 polyadenine tracts result in early termination of its messenger RNA translation, leading to protein degradation or generation of truncated ACVR2A proteins; further, none of the three mutants could activate downstream signaling pathways.
Fig.1 Activins’ potential bifunctionality.1
Involvement in disease
In previous studies, many scientists have extended their characterization of ACVR2A as a potential genetic risk factor for pre-eclampsia. Studies also showed that mutated ACVR2A lost the function of promoting migration mediated by wild-type ACVR2A through activin signaling in colon cancer and attenuated activin signaling in prostate cancer cells. Mutated ACVR2A was significantly associated with microsatellite instability-high (MSI-H) in gastric cancer (GC), making it a potential biomarker that could be useful in choosing candidates for immunotherapy.
Increase Your Chance for Paramount Discoveries
Our expert team of recognized thought leaders has decades of experience developing, validating, and implementing biomarker assays designed to meet the specific needs of context of use to support your academic research use.
Creative Biolabs validates all antibodies on WB, IHC, ICC, IF, and ELISA with known positive and negative samples to ensure specificity and high affinity. We also offer antibody labeling services using our catalogue of antibody products and a broad range of intensely fluorescent dyes and labels. Creative Biolabs also provides stable cell lines development services to explore the function and possible mechanism of wild-type ACVR2A and its mutants in regulating cell migration and proliferation.
| Cat | Service |
| BAS74-1 | Stable Cell Line Generation Services |
| BAS74-2 | ACVR2A Expression Analysis |
| BAS74-3 | ACVR2A SNP Genotyping |
Please don't hesitate to contact us today to develop custom solutions for specific needs. We will work to accommodate your request.
Reference
- Olsen, Oddrun Elise, et al. "Activins as dual specificity TGF-β family molecules: SMAD-activation via activin-and BMP-type 1 receptors." Biomolecules 10.4 (2020): 519. Distributed under Open Access license CC BY 4.0, without modification.
For Research Use Only.
