Up to now, the functional characteristics of ATP-binding cassette subfamily A member 10 (ABCA10) are yet unknown. Previous genome-related studies indicated that variants of ABCA10 gene might be linked to deaths related to follicular lymphoma. Creative Biolabs now provides a wide range of customized ABCA10 analytical services for global clients. Our top-class research teams and diversified technology platforms ensure various analytical services worthy of your trust.
Scientific Validity
Being the largest family of human transfer protein genes, the ABC transporter subfamily can be divided into seven subfamilies, namely ABCA, ABCB, ABCC, ABCD, ABCE, ABCF, and ABCG. Most of these ABC proteins are membrane-bound proteins transporter proteins responsible for the traffick of many biomolecules. Among them, ABCA10 gene is highly expressed in the gastrointestinal tract and is closely related to macrophages lipid homeostasis. ABCA10 plays a crucial role in the maintenance of homeostasis in vivo. Unfortunately, the exact mechanism of this process remains unclear.
ABCA10: A potential biomarker of breast cancer
Recent studies have focused on the relationship between ABCA10 and cancer to evaluate the potential value of ABCA10 gene in the diagnosis, prognosis, and treatment of cancers. A newly published study confirmed that ABCA10 is closely related to immune-related pathways, including B cell, CD8+ T cell, CD4+ T cell, Macrophage, neutrophil, and DC activation. The expression level of ABCA10 in vivo is closely related to the pathological stage of breast cancer patients.
As shown in Fig.1, the expression of ABCA10 is downregulated in different subgroups of breast cancer and extremely relevant to pathological stage in BRCA patients. The expression level of ABCA10 is negatively correlated with the survival of BRCA patients. Hence, ABCA10 may be an effective target for the treatment and prognosis evaluation of breast cancer.
Fig.1 Transcriptional level of ABCA10 in BRCA. (Chu, 2022)
Services at Creative Biolabs
Creative Biolabs provides distinguished and precise analysis services for ABCA10 identification and quantification. We harbor the world-class researchers and a large number of precision instruments to meet your different analytical needs. The emphasis on core technology allows us to complete the biomarker analysis more quickly and professionally. At Creative Biolabs, you can find a variety of ABCA10 testing and analysis services as shown below.
- ABCA10 protein level test (ELISA, LFA, CLIA, LEIA, etc.)
- Western blot assay
- ABCA10 gene sequencing
- Other customized ABCA10 services
With professional research teams and multifarious technology platforms, Creative Biolabs is a loyal partner for your academic research and product development. We also provide services for the development of potential therapeutic targets by combining computational and biological assays.
If you have any requirements for ABCA10 analysis, please do not hesitate to contact us for more information.
Reference
- Chu, P. Y.; et al. Downregulation of ATP binding cassette subfamily a member 10 acts as a prognostic factor associated with immune infiltration in breast cancer. Aging (Albany NY). 2022, 14(5): 2252.
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