ABCA10 analysis is instrumental in identifying and validating novel biomarkers for early disease detection, prognosis, and therapeutic response prediction, particularly in various cancers and lipid-related disorders. This enables more effective patient stratification and monitoring, leading to improved disease management.
At Creative Biolabs, our team of seasoned biologists and cutting-edge technology platforms is dedicated to advancing your research. We provide comprehensive ABCA10 analysis services, offering a variety of strategic options to help you unlock novel insights and accelerate your drug discovery and diagnostic development efforts.
Introduction of ABCA10
ABCA10 (ATP-binding cassette subfamily A member 10), a pivotal ABC transporter, is essential for cellular homeostasis by transporting diverse molecules across membranes. Primarily studied in human macrophages, it's widely expressed in tissues like the heart, brain, and GI tract. ABCA10 critically regulates macrophage lipid homeostasis and intracellular sterol transport, with its expression influenced by cholesterol, preventing lipid-induced cellular toxicity.
ABCA10: A Potential Biomarker of Breast Cancer
Emerging research highlights ABCA10's significant role in oncology. Its frequent downregulation in breast cancer subgroups correlates with pathological stage and shorter patient survival. Beyond breast cancer, ABCA10 gene variants are linked to follicular lymphoma outcomes. Its influence on the tumor microenvironment, including immune cell infiltration and immunotherapy responses, positions ABCA10 as a promising prognostic factor, therapeutic target, and valuable biomarker in precision oncology.
Fig.1 Transcriptional level of ABCA10 in BRCA.1
ABCA10 Analysis Services at Creative Biolabs
Creative Biolabs provides distinguished and precise analysis services for ABCA10 identification and quantification. Our world-class researchers and extensive precision instrumentation are meticulously aligned to meet your diverse analytical needs. Our unwavering emphasis on core technology ensures that we complete biomarker analysis swiftly and with unparalleled professionalism. At Creative Biolabs, you will discover a comprehensive array of ABCA10 testing and analysis services tailored to your research.
- ABCA10 Protein Level Testing
We offer highly sensitive techniques, including Enzyme-Linked Immunosorbent Assay (ELISA), Lateral Flow Assay (LFA), Chemiluminescence Immunoassay (CLIA), Luminescence Enzyme Immunoassay (LEIA), Western Blot assay, and Immunofluorescence for accurate ABCA10 protein quantification and localization.
- ABCA10 Gene Level Testing
Our advanced capabilities include ABCA10 gene sequencing, RNA-seq, and quantitative PCR (qPCR) for precise mRNA level quantification, alongside comprehensive Copy Number Variation (CNV) analysis.
- Integrated Bioinformatics Analysis
We leverage robust computational pipelines and publicly available datasets to provide deep insights into ABCA10's correlations with clinical outcomes, immune infiltration, and potential drug interactions.
- Customized ABCA10 Solutions
Recognizing the unique nature of each research project, we offer bespoke analytical services designed to address your specific experimental requirements and objectives.
Service Workflow
Our ABCA10 analysis service follows a structured, step-by-step workflow for efficiency and precision:
01Initial Consultation
We begin with a detailed discussion with our scientific experts to thoroughly understand your research goals, sample nature, and unique analytical requirements. This ensures our approach aligns perfectly with your objectives.
02Sample Submission
Clients securely provide necessary biological materials (e.g., tissue biopsies, blood, plasma, isolated cells, RNA/DNA). Each sample undergoes rigorous quality control upon reception, ensuring high-quality materials for reliable results.
03Experimental Execution
With verified samples, our expert team meticulously applies agreed-upon methodologies. This includes sophisticated protein assays (e.g., ELISA, Western blot) or gene-level analyses (e.g., sequencing, RNA-seq) for accurate ABCA10 quantification, mutation detection, and insightful pathway correlation using our cutting-edge instrumentation.
04Data Analysis & Interpretation
Complex raw data is processed and analyzed using advanced bioinformatics tools. This involves rigorous statistical analysis, pathway mapping, and comparative analysis to transform measurements into meaningful biological insights, highlighting significant trends and implications of ABCA10 expression or mutation.
05Comprehensive Reporting
Finally, we deliver a detailed final report with thoroughly analyzed data, clear figures, expert interpretations, and actionable conclusions. This report includes methodologies, key findings, and recommendations for future research, empowering your team with intelligence for scientific breakthroughs.
Applications
Biomarker Discovery and Validation
Target Identification and Drug Development
Understanding ABCA10's expression, function, and genetic alterations provides crucial insights for identifying and validating it as a potential therapeutic target, thereby accelerating the drug discovery pipeline. Such validation speeds up rational drug design and reduces development risks.
Personalized Medicine Strategies
By characterizing individual ABCA10 profiles, our analysis supports the development of personalized treatment strategies, optimizing therapeutic outcomes based on specific patient molecular signatures. This precision approach enhances treatment efficacy and minimizes adverse effects.
Mechanistic Insights into Disease Pathogenesis
Detailed ABCA10 analysis contributes to a deeper understanding of its precise role in the complex mechanisms underlying lipid metabolism disorders, cancer progression, and neurodegenerative diseases. These foundational insights drive new therapeutic avenues and prevention strategies.
Service Highlights
- Expert Scientific Team: Our services are powered by a team of highly experienced biologists and bioinformatics specialists, ensuring profound scientific understanding and accurate data interpretation for every project.
- Advanced Technology Platform: We utilize state-of-the-art instrumentation and validated methodologies, guaranteeing high sensitivity, specificity, and reproducibility in all ABCA10 analysis procedures.
- Customized Analytical Solutions: We offer highly flexible and tailored analytical strategies, adapting our services to meet the precise and unique requirements of your research objectives.
- Actionable Data and Insights: Beyond raw data, we deliver clear, comprehensive reports with actionable insights, facilitating informed decision-making and accelerating your research and development efforts.
FAQs
-
Can you assist with interpreting the complex results of ABCA10 analysis?
Absolutely, our expert scientific team provides comprehensive data interpretation services, translating raw analytical outputs into meaningful biological insights and actionable conclusions relevant to your research objectives. Our interpretations empower well-informed decision-making for your next steps.
-
How do you ensure the quality and accuracy of ABCA10 analysis results?
We maintain stringent quality control measures throughout every stage of the ABCA10 analysis workflow, from sample reception and preparation to data acquisition and interpretation, ensuring high accuracy and reliability of all results. Our protocols strictly adhere to established industry best practices.
-
Can I request a customized ABCA10 analysis tailored to my specific research needs?
Yes, Creative Biolabs specializes in offering highly customized ABCA10 analysis solutions, and we encourage clients to discuss their unique research requirements during the initial consultation to design a bespoke service plan. This ensures maximum relevance and impact to your study's goals.
-
Is ABCA10 analysis relevant for studies beyond cancer and lipid metabolism?
While ABCA10 is extensively studied in cancer and lipid metabolism, its role is continuously being uncovered in other areas, and we can discuss its potential relevance to your specific field of interest, such as neurodegenerative diseases. We warmly welcome diverse research inquiries to explore new frontiers.
-
Do you provide support for downstream experiments based on ABCA10 analysis results?
While our primary service focuses on ABCA10 analysis, we are pleased to offer scientific consultation and recommendations for potential downstream experimental pathways, leveraging our extensive expertise to guide your ongoing research. We aim to foster long-term, collaborative scientific partnerships.
With professional research teams and multifarious technology platforms, Creative Biolabs is a loyal partner for your academic research and product development. We also provide services for the development of potential therapeutic targets by combining computational and biological assays.
If you have any requirements for ABCA10 analysis, please do not hesitate to contact us for more information.
Reference
- Chu, Pei-Yi et al. “Downregulation of ATP binding cassette subfamily a member 10 acts as a prognostic factor associated with immune infiltration in breast cancer.” Aging vol. 14,5 (2022): 2252-2267. doi:10.18632/aging.203933. Distributed under Open Access license CC BY 3.0, without modification.
For Research Use Only.
