Biomarker assays and analysis readouts are important tools in drug discovery from target validation studies to candidate selection. Therefore, the ability to measure with sensitivity and accuracy is important in making critical go/no-go study decisions. With years of experience in biomarker analysis and solution design, Creative Biolabs can support your asdenosine A2B receptor (ADORA2B) research pipeline by providing biomarker analysis. Our available services work perfectly as either standalone or part of an end-to-end, well-integrated preclinical program.
Introduction
ADORA2B encodes a protein belonging to the G protein-coupled receptor superfamily and is highly expressed in various carcinomas, leading to the promotion of cancer cell proliferation and metastasis. ADORA2B also regulates the tumor microenvironment and is involved in peripheral vascular growth, inflammatory cell infiltration, fibroblast proliferation, and extracellular matrix accumulation.
Fig.1 Diagrammatic depiction of ADORA2B’s involvement in diverse human pathologies.1
ADORA2B is an indispensable target in the regulation of both acute and chronic pulmonary diseases, such as pulmonary hypertension, chronic obstructive pulmonary disease, and pulmonary fibrosis. Growing evidence indicates that ADORA2B might serve as a target for novel therapies or co-therapies for these diseases.
We Have Your Biomarker Assay Needs Covered
At Creative Biolabs, significant advances have been made in our understanding of ADORA2B. We focused our attention on the relationship between ADORA2B and Fra-1.
At Creative Biolabs, the mRNA expression levels, protein expression levels, various mutations, copy number variations, and related network signaling pathways of ADORA2B could be analyzed with the help of our advanced platforms. Armed with years of antibody development experience, Creative Biolabs has developed ADORA2B antibodies raised against different fragments of ADORA2B. Our antibody can be used in WB, IHC, live cell imaging and indirect flow cytometry applications. They have been designed to recognize ADORA2B from human, rat, and mouse samples. Our services include but not limited to the following:
- IHC
- Flow cytometry
- ELISA
- mRNA expression
- Immunoblotting analysis
- GPCR assay
If you are interested in our services, please contact us for more information.
Reference
- Sun, Ying, and Pingbo Huang. "Adenosine A2B receptor: from cell biology to human diseases." Frontiers in chemistry 4 (2016): 37. Distributed under Open Access license CC BY 4.0, without modification.
For Research Use Only.
