ADAM7 (ADAM Metallopeptidase Domain 7) is part of the ADAM family of disintegrins and metalloproteases. Creative Biolabs offers one-stop services for ADAM7 using our advanced biomarker analysis platform technologies. Our full services include gene/protein expression analysis, mutation analysis, and diverse custom antibody-based assay development services. We offer significant cost saving advantages and record speed in data analysis. Creative Biolabs also has extensive experience and expertise in handling various types of molecular assays.
Background
ADAM7 is synthesized as a protein and secreted by corpus and cauda epididymus. It plays roles in multiple processes including cell signaling, adhesion, and migration. Diseases associated with ADAM7 include Melanoma. Among its related pathways is Notch Signaling.
Fig.1 Domain architecture of ADAM/TS-TSL family members represented schematically.1
Scientists found that the phosphorylation of p38MAPK was significantly inhibited in ADAM7 silenced cells while it was significantly induced in ADAM7 overexpressed cells. Mutations in ADAM7 may be involved in the progression of melanoma.
Increase Your Chance for Paramount Discoveries
At Creative Biolabs, pre-made anti-ADAM7 benchmark inhibitory mAb is expressed by mammalian cell line for cell culture, FACS, ELISA, functional assay development, PK/PD model development, and mechanism of action (MOA) research.
Creative Biolabs offers biomarker analysis services through a network of experts familiar with the multifaceted nature of biomarker selection, validation, and application from drug discovery to preclinical sample analysis supporting decision making and mitigating risk at key stages of your program. Our major services include but are not limited to the following:
| Cat | Service |
| BAS75-1 | ADAM7 Knockdown Service |
| BAS75-2 | ADAM7 Expression Analysis Service |
| BAS75-3 | In situ Hybridization Service |
| BAS75-3 | Chromosomal Mapping Service |
| BAS75-4 | ADAM7 Mutational Analysis |
| BAS75-5 | Construction of Wild-type and Mutant ADAM7 Expression Vector |
| BAS75-6 | ADAM7 Activity Measurement |
- ADAM7 knockdown service
- ADAM7 expression analysis service
- In situ hybridization
- Chromosomal mapping
- ADAM7 mutational analysis
- Construction of wild-type and mutant ADAM7 expression vector
- ADAM7 Activity Measurement
The key to the ADAM7 fluorescent assay is the fluorogenic substrate. Using innovative assay at Creative Biolabs, only one simple step on a microtiter plate is required for ADAM7 reactions. A sample containing ADAM7 will be incubated in a reaction mixture with the fluorogenic substrate and fluorescence is measured using a plate reader.
Please don't hesitate to contact us today to develop custom solutions for specific needs. We will work to accommodate your request.
Reference
- Théret, Nathalie, et al. "ADAM and ADAMTS proteins, new players in the regulation of hepatocellular carcinoma microenvironment." Cancers 13.7 (2021): 1563. Distributed under Open Access license CC BY 4.0, without modification.
For Research Use Only.
