To fully realize the benefits of biomarker research, you may need early insights, focused expertise, and a clear blueprint that includes the most advanced platforms and techniques. As a leading one-stop CRO company, Creative Biolabs provides our clients with comprehensive angiotensin II receptor type 1 (AGTR1) analysis services beginning with a deep understanding of the role of AGTR1 in your program, the proposed application, and which tools will help you achieve your goals. Customers can choose from a range of validated assays for immune cell function, toxicology, neurobiology, and drug development.
Diagnostic Powder
AGTR1 acts as a novel component of the renin-angiotensin system (RAS) to affect blood pressure and heart hypertrophy. Now the AGTR1 blocker has been applied in clinical oncology, such as for breast cancer and prostate cancer.
Moreover, AGTR1 methylation had been extensively recognized as an effective biomarker for various human cancer diagnoses such as non‑small cell lung cancer (NSCLC), colorectal cancer, oral squamous cell carcinoma, breast cancer, oral cancer, and ovarian cancer. AGTR1 hypermethylation is also a promising biomarker to assist in lung squamous cell carcinoma (LUSC) detection and diagnosis.
Currently, emerging evidence showed that AGTR1 regulates cell proliferation during cancer development, and promotes tumor invasion, migration, metastasis, and angiogenesis. Therefore, AGTR1 detection is necessary and urgent.
Fig.1 Key AGTR1-mediated signaling routes associated with tumor cell growth, angiogenic processes, and EMT.1
Biomarker research to the next level?
High yields of functional and stable membrane proteins are hard to be obtained. In recent years, Creative Biolabs has mastered the most commonly used strategies and methods for membrane protein reconstitution. Aided by our membrane protein antibody discovery platform, Creative Biolabs provides customized AGTR1 analysis services at both the gene level and protein level. Our popular services include but are not limited to the following:
| Cat | Service |
| BAS80-1 | AGTR1 Protein Expression Analysis |
| BAS80-2 | AGTR1 mRNA Expression Analysis |
| BAS80-3 | AGTR1 Genotyping Analyses |
| BAS80-4 | AGTR1 Mutation Analysis |
Creative Biolabs offers one-stop-shop custom antibody development services for a certain application. We have spent many years optimizing and fine-tuning specific parameters throughout the biomarker analysis, starting from project design to data analysis. We built our advantage on the competitiveness of our technology and efficiency.
If you are interested in our services, please don't hesitate to contact us today to develop a custom solution for specific needs. We will work to accommodate your request.
Reference
- Singh, Anukriti, Jessica J. Nunes, and Bushra Ateeq. "Role and therapeutic potential of G-protein coupled receptors in breast cancer progression and metastases." European Journal of Pharmacology 763 (2015): 178-183. Distributed under Open Access license CC BY 4.0, without modification.
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