As a globally recognized contract research organization (CRO) in biomarker research, Creative Biolabs has committed to biomarker-driven development programs with a strong focus on biomarker assay development. We specialize in developing new technologies and customized approaches for biomarker assay to generate rich, multi-omic biomarker data from our global footprint. At present, Creative Biolabs provides custom type-2 angiotensin II receptor (AGTR2) analysis services for worldwide clients.
Fig.1 Comprehensive biomarker analysis services at Creative Biolabs.
Background
Angiotensin II is a potent vasopressor hormone that acts through at least two types of receptors, AGTR1 and AGTR2. AGTR2 is a seven transmembrane G protein-coupled receptor (GPCR), but AGTR2 does not demonstrate most of the classic features of GPCR signaling. AGTR2 is involved in a wide range of activities, such as the induction of neurite outgrowth, the mediation of vasoconstriction, and the inhibition of cellular proliferation.
Fig.2 Structure of AGTR2.1
AGTR2 Diagnostic Power
The AGTR2 expression is upregulated in pathophysiological situations involving tissue remodeling, inflammation, and/or repair. Upregulation of AGTR2 is also observed in a variety of tumors, including but not limited to the ductal and invasive breast carcinoma, gastric cancer and lymph node metastases, high-grade astrocytoma, and high-grade renal cell carcinoma. Besides, mutations in the coding region of the AGTR2 were identified to cause X-linked recessive mental retardation.
We Have Your Biomarker Assay Needs Covered
Creative Biolabs leverages established technologies, proprietary approaches, and develops and validates biomarker assays to generate robust biomarker data in samples ranging from nucleic acids to tissues. We validate our self-developed anti-AGTR2 antibodies on ELISA, WB, IHC, ICC, and IF with known positive and negative samples to ensure specificity and high affinity. ELISA methods have been developed for the in vitro quantitative measurement of human AGTR2 concentrations in serum, plasma, and other biological fluids. Our AGTR2 analysis mainly includes but is not limited to the following:
| Cat | Service |
| BAS77-1 | AGTR2 mRNA Expression Analysis |
| BAS77-2 | AGTR2 Protein Expression Analysis |
| BAS77-3 | AGTR2 SNP Genotyping Assay |
| BAS77-4 | AGTR2 Mutation Detection |
Membrane proteins are one of the most attractive and challenging objects since they are important therapeutic targets, but difficulties exist in the study of their structure and function. Among them, AGTR2 has been widely studied for its role in blood-pressure regulation and renal and cardiovascular health.
If you are interested in our services, please don't hesitate to contact us today to develop custom solutions for specific needs. We will work to accommodate your request.
Reference
- Liu, Xiaoyan, et al. "Pre-miRNA Hsa-Let-7a-2: a novel intracellular partner of angiotensin II type 2 receptor negatively regulating its signals." International Journal of Biological Sciences 18.8 (2022): 3237. Distributed under Open Access license CC BY 4.0, without modification.
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