Creative Biolabs is an industry leader in bioscience services with a strong focus on biomarker reagent development and assay development. Our comprehensive solution starts with a foundation of expertise in biomarker analysis such as immune monitoring, genomics, and bioanalysis. Creative Biolabs specializes in proposing customized approaches for biomarker assay to generate rich data from our global footprint. The success of our established methodology distinguishes us from other CRO and biomarker labs.
Background
The 252-kDa nucleoporin ELYS, encoded by AHCTF1 gene, is a large multifunctional protein with critical roles in nuclear pore assembly and mitosis. ELYS is one of 10 components of the large NUP 107-160 subunit of nuclear pore complexes (NPCs). These huge multi-subunit complexes form cylindrical channels in the nuclear envelope that regulate nucleocytoplasmic transport and intracellular localization of large molecules. ELYS is also indispensable for NPC reassembly after mitosis and carries out a broad range of activities during the cell cycle, such as mitotic spindle assembly, chromatin decompaction, and chromosome segregation.
Fig.1 AHCTF1 involved in WNT/ß-catenin-AHCTF1-CTCF-eRNA signaling pathways.1
Biomarker research to the next level?
Previous in vivo cancer studies provide a strong and feasible rationale for targeting ELYS for the treatment of a broad spectrum of cancers. Creative Biolabs leverages established technologies, proprietary approaches, and develops & validates biomarker assays to generate robust biomarker data in samples ranging from nucleic acids to tissues. Figure 2 shows our comprehensive biomarker assay services.
Fig.2 Biomarker analysis service at Creative Biolabs.
Using the packaged analysis solution, Creative Biolabs can realize a comprehensive analysis of the target, and mine the available data to the greatest extent. For ELYS protein, the popular analysis services include but are not limited to the following:
| Cat | Service |
| BAS81-1 | ELYS Protein Expression Analysis |
| BAS81-2 | ELYS Knockdown Assay |
| BAS81-3 | Cryo-EM Analysis of the ELYS-nucleosome Complex |
| BAS81-4 | Crosslinking Mass Spectrometric Analysis |
| BAS81-5 | In vitro Binding Assay |
Creative Biolabs also offers one-stop custom antibody development services for certain applications. We have spent many years optimizing and fine-tuning specific parameters throughout the biomarker analysis, starting from project design to data analysis. We built our advantage on the competitiveness of our technology and efficiency.
If you are interested in our biomarker analysis services, please don't hesitate to contact us today to develop custom solutions for specific needs. We will work to accommodate your request.
Reference
- Chachoua, Ilyas, et al. "Canonical WNT signaling-dependent gating of MYC requires a noncanonical CTCF function at a distal binding site." Nature communications 13.1 (2022): 204. Distributed under Open Access license CC BY 4.0, without modification.
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