Reported data collectively point angiomotin (AMOT) as a potential prognostic biomarker and therapeutic target in cancer. As a worldwide CRO company, Creative Biolabs has accumulated extensive experience in diverse areas of research including cardiovascular disease, cancer, infection, inflammation, and so forth. We offer quantitative biomarker profiling on our high-throughput analysis platform. The analysis service is highly standardized which allows you to benefit from affordable pricing and fast delivery times.
Background
AMOT is a transmembrane protein that is aberrantly expressed in a variety of solid tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. Accumulating evidence support that AMOT is involved in the pathological processes of tumor proliferation, apoptosis, and invasion.
Biomarker Research to the Next Level?
AMOT has two isoforms with MW 130 kDa (p130) and 80 kDa (p80). Some studies have evaluated the expression of AMOT-p130 and AMOT-p80 in many cell lines as shown in Table 1. At Creative Biolabs, pre-made anti-AMOT benchmark inhibitory mAb is expressed by mammalian cell line for AMOT protein quantification and localization, FACS, ELISA functional assay, affinity binding assay, animal model development, PK/PD model development, and mechanism of action research.
Table 1 The expression and location of AMOT isoforms.
Creative Biolabs has already developed isoform-specific antibodies for p130 or p80 identification. With the development of powerful technologies for proteomics, PTM analysis, protein quantitation, we now offer custom biomarker analysis for global clients. To understand the functions of AMOT and their place in complex biological systems, it is often important to measure changes in protein abundance relative to changes in the state of the system. These measurements have been performed using WB, IHC, ICC, IF, ELISA and so forth.
| Cat | Service |
|---|---|
| BAS99-1 | AMOT Expression Analysis |
| BAS99-2 | AMOT-TNKS Interaction Analysis |
| BAS99-3 | AMOT-AMOTL1 Interaction Analysis |
| BAS99-4 | Cell Cycle Analysis |
| BAS99-5 | AMOT Isoform Identification |
| BAS99-6 | Lateral Flow Assay Development |
At Creative Biolabs, we work with clients to develop assays for a wide range of biomarkers and sample types, with emphasis on in vivo disease biomarker diagnosis. If you are interested in our services, please don't hesitate to contact us today to develop custom solution for specific needs. We will work to accommodate your request.
For Research Use Only.
