Serum angiopoietin-2 (ANGPT2) is a potential biomarker for predicting clinical outcomes of immune checkpoint therapy. Creative Biolabs now provides a diverse range of ANGPT2 analysis services for research use. Our experience in providing biomarker solutions for complex applications is unapparelled in the industry. Scientists at Creative Biolabs are experts in finding the optimum analytical strategy for ANGPT2 detection, analysis, and data interpretation.
Introduction
ANGPT2, a ligand of the receptor tyrosine kinase TIE2, functions as a vessel-destabilizing molecule and is a critical regulator of blood vessel maturation. ANGPT2 is low in normal tissues but often highly upregulated in the tumor vasculature. Elevated circulating ANGPT2 has been associated with poor prognosis and more invasive tumors in a variety of cancers and cardiovascular diseases such as acute aortic dissection (AAD). Besides, SNPs in ANGPT2 have been investigated for their association with breast and lung cancers.
- ANGPT2 SNPs (rs1868554, rs2442598) are significantly associated with acute lung injury.
- ANGPT2 SNPs (rs2442598, rs734701, rs1823375, rs11137037, rs1267482) are associated with the risk of developing rheumatoid arthritis.
Besides, researchers have clarified that serum ANGPT2 is a potent biomarker for predicting clinical outcomes of immune checkpoint therapy as well as a possible target for synergistic combination treatments.
Fig.1 ANGPT2 participates in fatty acid transport.1
We Have Your Biomarker Assay Needs Covered
Creative Biolabs has developed a panel of high activity TIE2 and ANGPT2 proteins from different species for studying the biology of the ANGPT2/TIE2 pathway. We also developed a series of antibodies targeting ANGPT2/TIE2 or related molecules. These antibodies can be used in ELISA, FCM, WB, ICC, IF, and IP.
Especially, matched antibody pairs are also available for custom assay development. For instance, a biotinylated anti-ANGPT2 mAb binds to the streptavidin-coated donor beads and its paired anti- ANGPT2 antibody is conjugated to our proprietary acceptor beads. In the presence of the ANGPT2, the beads come into proximity. The excitation of the donor beads causes the release of singlet oxygen molecules that triggers a cascade of energy transfer in the acceptor beads. The human ANGPT2-coupled magnetic beads are also available for custom assay development.
Our popular ANGPT2 analysis services include but are not limited to the following:
| Cat | Service |
| BAS90-1 | ANGPT2 Protein Analysis |
| BAS90-2 | ANGPT2 mRNA Analysis |
| BAS90-3 | Biomolecular Interaction Analysis |
| BAS90-4 | ANGPT2 Gene Expression Profiling |
| BAS90-5 | ANGPT2 Antibody Detection |
| BAS90-6 | ANGPT2 Mutants Generation and Expression |
| BAS90-7 | Custom ANGPT2 Assay Development |
Creative Biolabs prides us on our years of experience as pioneers in biomarker science to provide insight into what the data means for your research and how it can be applied to advance the development of your therapeutics. If you are interested in our services, please feel free to contact us for more information.
Reference
- Bae, Hosung, et al. "Angiopoietin-2–integrin α5β1 signaling enhances vascular fatty acid transport and prevents ectopic lipid-induced insulin resistance." Nature communications 11.1 (2020): 2980. Distributed under CC BY-SA 4.0, without modification.
For Research Use Only.
