Previous cell-based, animal, and clinical studies have collectively identified angiopoietin-like 4 (ANGPTL4) as a prognostic and diagnostic biomarker for diseases such as renal cell carcinoma (RCC), cholangiocarcinoma, and diabetic retinopathy (DR). Creative Biolabs offers an extensive menu of assays to provide flexible solutions achieving more comprehensive understanding of ANGPTL4. Our analysis services have an international reach and employ the latest technology and methodologies so that you get the most accurate and reliable results. Our expert staff are trained to the highest standards and have an in-depth knowledge of their fields and your business needs.
Introduction
ANGPTL4 is a circulating glycoprotein that structurally belongs to the angiopoietin/ANGPTL family. As Fig.1 shown, the human ANGPTL4 protein consists of 406 aa with a signal peptide directing secretion, an amino terminal coiled-coil domain, a linker, and a carboxy-terminal fibrinogen-like domain. The most studied function of ANGPTL4 is its effects on regulating lipid metabolism.
Fig.1 Structure of ANGPTL4.Distributed under CC BY-SA 4.0, from Wiki,
without modification.
We Have Your Biomarker Assay Needs Covered
It is well-known that noninvasive blood-based biomarkers can be used to monitor response to therapy, guide treatment decisions, and detect the early recurrence of the disease. Tremendous efforts have been devoted to developing diagnostic techniques for the detection of such blood-based protein biomarkers.
Among various approaches, ELISA is the most commonly used method for serum ANGPTL4 detection. As a novel alternative, the aptasensor can be a robust and simple approach for sensitive, specific, and convenient detection of ANGPTL4.
Besides, abundant evidence has opened the way to speculate a potential synergic role of PPARs and ANGPTL4 as key players in the cross talk between metabolic syndromes and cancer. Creative Biolabs also provides customized protein-protein interaction analysis services.
Fig.2 Cross-talk possibilities between lipid and glucose metabolism in oncogenesis.1
The ANGPTL4-related reagents such as antibodies and protein supplied by Creative Biolabs are manufactured under a strict quality control system. Led by our professional R&D team focused on key diagnostic areas, the design for your biomarker program is informed by industry insights and deep specialized knowledge around three key areas: gene level analysis, protein level analysis as well as an integrated solution. Our popular services include but are not limited to the following:
| Cat | Service |
| BAS88-1 | ANGPTL4 Protein Analysis |
| BAS88-2 | ANGPTL4 mRNA Analysis |
| BAS88-3 | Establishment of ANGPTL4-overexpressing Cells |
| BAS88-4 | ANGPTL4 Knockdown Assay |
| BAS88-5 | ANGPTL4 Aptamers Screening |
| BAS88-6 | Aptasensor Development |
| BAS88-7 | ANGPTL-XXX Interaction Assay |
If you are interested in our services, please feel free to contact us for more information.
Reference
- La Paglia, Laura, et al. "Potential role of ANGPTL4 in the cross talk between metabolism and cancer through PPAR signaling pathway." PPAR research 2017 (2017). Distributed under CC BY-SA 4.0, without modification.
For Research Use Only.
