Creative Biolabs has been focusing on the biomarker detection area for many years. Currently, we have launched a series of IVD biomarker analysis services. We now provide one-stop BABAM2 analysis services for global clients.
Overview of BABAM2
BABAM2, a core component of the deubiquitin complex, plays an important role in a variety of signaling pathways. BABAM2 interacts with other biomarker in vivo to indirectly induce cell cycle arrest and apoptosis or lead to the survival of cells with damaged DNA. Reported studies showing that evidence that BABAM2 plays an important role in regulating cell cycle progression and pluripotency status following DNA damage.
Fig.1 BRCC45 overexpression confers survival advantage in BRCA2-deficient cells.1
Frontier Research
mRNA of BABAM2 can be detected in a variety of cancers. Antibodies targeting BABAM2 are often used in the immunohistochemical detection of breast cancer, cervical cancer, rectal cancer for research use.
BABAM2 can be multiple gynecological malignancies biomarker. In particular, gynecological clear cell carcinoma is an aggressive tumor with a high resistance rate to conventional platinum-based chemotherapy, whose molecular characteristics are still largely unknown, and for which there are no targeted therapies. In a recent study, BABAM2-ALK fusion by next-generation sequencing (NGS) was confirmed, which may be a pathogenic mechanism in this carcinoma. Findings also suggest that BABAM2 expression reflects favorable prognosis in breast cancer patients receiving radiation therapy.
Services Provided by Creative Biolabs
The studies on BABAM2 mainly used immune and molecular experiments in cell transfection and animal model tissue analysis, to determine the role of BABAM2. Nowadays, Creative Biolabs is committed to offering integrated analysis services for every step of your research.
Our services can be customized to suit the specific needs of our clients, popular analysis services targeting BABAM2 include but are not limited to the following:
| Immunology Diagnostic Platform | |
|---|---|
| Cat | Service |
| BAS105-1 | BABAM2 Antibody Development |
| BAS105-2 | BABAM2 Protein Ubiquitination Assay |
| BAS105-3 | Immunofluorescence Assay |
| BAS105-4 | Immunohistochemical Analysis |
| BAS105-5 | Co-Immunoprecipitation Assay |
| BAS105-6 | BABAM2 Fusion Protein Development |
| Molecular Diagnostic Platform | |
|---|---|
| Cat | Service |
| BAS105-7 | BABAM2 PCR Assay |
| BAS105-8 | BABAM2 Sequencing Assay |
| BAS105-9 | BABAM2 Gene KO/Over-expression Plasmid Development |
| BAS105-10 | BABAM2 Gene KO/Over-expression Cell Production |
Creative Biolabs is committed to providing the highest quality of custom services and products at the most reasonable prices. Please feel free to contact us for more information and a formal quote.
Reference
- Biswas, Kajal, et al. "BRE/BRCC45 regulates CDC25A stability by recruiting USP7 in response to DNA damage." Nature communications 9.1 (2018): 537. Distributed under CC BY-SA 4.0, without modification.
For Research Use Only.
