Creative Biolabs provides global clients with a one-stop service for Brca1-associated protein (BAP1) biomarker analysis from protein expression and antibody development to genetic testing and data analysis as a support for academic diagnostic research.
BAP1 in Cancer
Many studies suggest that germline mutation of BAP1 results in a tumor predisposition syndrome linking BAP1 to cancers. Compiled from 97 PubMed articles on BAP1 mutation carriers published between 2011 and 2022, 553 of the 689 mutation carriers were developed cancer, 27% had two to seven tumor types.
Fig.1 Comprehensive overview of BAP1 functional roles.1
Services Provided by Creative Biolabs
Studies on BAP1 have shown that genetic testing for germ-line BAP1 mutations is recommended if the staining of BAP1 protein is absent in immunohistochemical assay. Moreover, more than 60% of sporadic mesothelioma and 100% of germ-line BAP1 mutation carriers of mesothelioma have BAP1 biallelic inactivation in their tumor cells. And the amount of BAP1 phosphorylation increased after UV damage to DNA.
BAP1-related researches involve a variety of laboratory assays. Creative Biolabs is competent to provide you with a comprehensive range of BAP1 analysis services. Our services can be customized to suit your specific needs. Popular analysis services targeting BAP1 include but are not limited to the following:
| Cat | Service |
|---|---|
| BAS106-1 | BAP1 Antibody Development |
| BAS106-2 | BAP1 Immunohistochemical Analysis |
| BAS106-3 | Normal/Loss BAP1 Protein Expression |
| BAS106-4 | BAP1-KO Cell Line Construction |
| BAS106-5 | BAP1 Genetic Testing |
| BAS106-6 | Germ-line BAP1 Mutations Analysis |
| BAS106-7 | BAP1 Deubiquitinates Assay |
| BAS106-8 | BAP1 Phosphorylation Detection |
If you are interested in our BAP1 analysis or you are looking for customized services, please feel free to contact us for more information.
Reference
- Louie, Bryan H., and Razelle Kurzrock. "BAP1: Not just a BRCA1-associated protein." Cancer treatment reviews 90 (2020): 102091. Distributed under CC BY-SA 4.0, without modification.
For Research Use Only.
