Armed with rich experience in biomarker tests, Creative Biolabs can insight into your IVD test, product development needs and provide one-stop Bromodomain Adjacent To Zinc Finger Domain 2B (BAZ2B) analysis services based on innovative test platforms.
BAZ2B Domain Organization
The secondary structure of different domains in BAZ2B may interact with a variety of proteins and DNA. It has been found that BAZ2B's tandem PHD-BRD domain can bind to acetylated histones H3 and H4. The mechanism can be further elucidated by studying the different domains of BAZ2B.
BAZ2B has four main domains that have unique characteristics for different functions, namely methyl binding domain (MAD), DNA binding homeobox and different transcription factors (DDT), plant homeodomain (PHD) and bromodomains.
- MBD domain bind methylated DNA
- PHD domain bind unmodified histones
- DDT domains enable DNA-binding abilities
- Bromodomains recognize acetylated histones
Fig.1 The structure of BAZ2B.1
New Research Exploration
Although the biological function of BAZ2B is still not fully understood, an increasing number of research suggests that BAZ2B is one of the potential therapeutic targets for different diseases. Recent studies on BAZ2B are as follows:
Allergic Asthma
BAZ2B can aggravate allergen-induced lung inflammation by promoting the activation of M2 macrophages, which is crucial in the progression of allergic asthma and is expected to be a potential diagnostic target for asthma in children.
Neurodevelopment
Loss of BAZ2B function has been postulated to cause neurodevelopmental disorders, thus cause of developmental delays, intellectual disabilities, and autism spectrum disorders.
Hematopoietic Lineage
BAZ2B can reprogram human hematopoietic lineage commitment progenitor cells into a pluripotent state and this cell possess long-term engraftment potential.
Others
BAZ2B overexpression is associated with unfavorable prognosis in children with B-cell acute lymphoblastic leukemia. The increased expression of BAZ2B in the aging brain may be an important cause of mitochondrial dysfunction in Alzheimer's disease and play an important role in the occurrence and development of Alzheimer's disease.
Services at Creative Biolabs
As one of the ISWI subfamily of human remodeling enzymes, BAZ2B produces a variety of complex forms. The research on it often requires domain screening analysis and compound identification analysis. Services at Creative Biolabs can be customized to suit the specific needs of our clients, popular analysis services targeting BAZ2B include but are not limited to the following:
| Cat | Service |
|---|---|
| BAS107-1 | BAZ2B Antibody Development |
| BAS107-2 | BAZ2B Inhibitor Screening Assay |
| BAS107-3 | BAZ2B Immunohistochemical Analysis |
| BAS107-4 | BAZ2B Structural Analysis |
| BAS107-5 | BAZ2B Sequencing Assay |
| BAS107-6 | BAZ2B-KO Cell Line Construction |
| BAS107-7 | BAZ2B DNA Binding Affinity Assay |
| BAS107-8 | BAZ2B DNA Methylation Assay |
| BAS133-9 | BAZ2B Complexes Recombinant Expression |
Creative Biolabs is committed to providing the highest quality of custom services and products at the most reasonable prices. Please feel free to contact us for more information and a formal quote.
Reference
- Tallant, Cynthia, et al. "Molecular basis of histone tail recognition by human TIP5 PHD finger and bromodomain of the chromatin remodeling complex NoRC." Structure 23.1 (2015): 80-92.
For Research Use Only.
