Reported studies have shown that overexpression of BCL2 causes tumor tolerance to chemotherapy drugs and seeking BCL2-targted therapy has emerged as a new research direction. Armed with rich experience in targeted therapy research, Creative Biolabs has an in-depth understanding of biomarker analysis, providing a comprehensive laboratory BCL2 assays for global clients. Our biomarker services can be offered as part of an integrated pre-clinical package or as stand-alone analytical options.
BCL2 Protein Family and Apoptosis
BCL2 protein family is one of the core regulatory mechanisms of apoptosis, which can receive and transmit internal intracellular signals or external environmental stress signals, such as nutrient or hypoxia stress, DNA damage, oncogene overactivation, endoplasmic reticulum stress and so forth. BCL2 has been linked to many tumors, psychiatric disorders, and autoimmune diseases. It plays an important role in the regulation of apoptosis by dimerizing with Bax protein in the same family and by itself dimerizing.
FFig.1 External and internal mechanisms of apoptosis.1, 3
BCL2 Inhibitors
BCL2 inhibitors can inhibit the binding of BCL2 protein to Bax protein to form dimer, so that the cell can resume the normal apoptosis process. BCL2 inhibitors can be used alone to kill cancer cells or in combination with other drugs to increase the sensitivity of cancer cells to the drug.
Fig.2 Specificity of different BCL2 inhibitor classes and their role in triggering apoptosis.2, 3
Services Provided by Creative Biolabs
At present, the researches on BCL2 mainly focuse on the development and validation of inhibitors. The first BCL2 inhibitor was successfully approved for the treatment of chronic lymphocytic leukemia (CLL) in 2016, and BCL2 gene has the advantage of low drug-resistant mutation rate, so combined with other therapies can produce more effective tumor response function.
Our services can be customized to suit the specific needs of our clients, popular analysis services targeting BCL2 and BCL2 inhibitors include but are not limited to the following:
| Cat | Service |
|---|---|
| BAS110-1 | BCL2 Antibody Development |
| BAS110-2 | BCL2 Protein Expression |
| BAS110-3 | BCL2 Sequence Assay |
| BAS110-4 | BCL2-KO Cell Line Construction |
| BAS110-5 | BCL2 Immunohistochemistry Assay |
| BAS110-6 | BCL2 Immunofluorescence Assay |
| BAS110-7 | BCL2 Western Blotting Assay |
| Cat | Service |
|---|---|
| BAS110-8 | BCL2 Inhibitor Screening Assay |
| BAS110-9 | BCL2 Apoptosis Assay |
| BAS110-10 | BCL2 Inhibitory Activity Assay |
| BAS110-11 | BCL2 Phosphorylation Analysis |
Creative Biolabs is committed to providing the highest quality of custom services and products at the most reasonable prices. Please feel free to contact us for more information and a formal quote.
References
- Kalkavan, Halime, and Douglas R. Green. "MOMP, cell suicide as a BCL-2 family business." Cell Death & Differentiation 25.1 (2018): 46-55.
- Hafezi, Shirin, and Mohamed Rahmani. "Targeting BCL-2 in cancer: advances, challenges, and perspectives." Cancers 13.6 (2021): 1292.
- Distributed under CC BY-SA 4.0, without modification.
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