Creative Biolabs offers high-throughput protein analyses with quantification and biomarker validation. With a focus on data quality and exceptional customer service, our in-house or external partner experts are here to help you accelerate your programmed cell death 6-interacting protein (PDCD6IP) analysis research.
Background
PDCD6IP, also well-known as ALIX, participates in concentration and sorting of cargo proteins of the multivehicular body or incorporation into intralumenal vesicles that are generated by invagination and scission from the limiting membrane of the endosome. PDCD6IP is required for apoptosis in a calcium-dependent manner. It also binds to endophilins which regulate membrane shape during endocytosis.
Diseases associated with PDCD6IP include Adult Neuronal Ceroid Lipofuscinosis. Besides, the association of PDCD6IP with non-small cell lung cancer and hepatocellular carcinoma has been reported in studies. Moreover, exosomal PDCD6IP combined with CA199 has great potentials in detection of pancreatic cancer, especially in distinguishing PC patients at early stages from advanced stages.
Analysis Services at Creative Biolabs
Designing your experiments with the PDCD6IP marker may be a challenge, but there are many tips to get you started. Creative Biolabs will help you get started with our advanced platforms. Our antibodies raised against PDCD6IP are highly specific and effective tools for analyzing human cells and samples. For instance:
- WB allows for the detection of PDCD6IP (and their PTMs) with far greater versatility and specificity than other antibody-based techniques. Creative Biolabs has included some general considerations on WB and detailed information on how WB can be used to analyze the various stages of apoptosis. Besides, IP is also a highly useful technique for detecting proteins contained within a complex.
- ELISA assay allows for the in vitro quantitative determination of PDCD6IP concentrations. Our assay has high sensitivity and excellent specificity for detection of PDCD6IP. No significant cross-reactivity or interference between PDCD6IP and analogues was observed.
- PDCD6IP interacts with and is phosphorylated by Src kinase at late endosomal membranes. Creative Biolabs also offers comprehensive PDCD6IP PTM analysis services for global clients.
Fig.1 Diagram depicting exosome formation and constituent components.1
Our popular analysis services targeting PDCD6IP include but not limited to the following:
| Cat | Service |
| BAS94-1 | PDCD6IP Protein Analysis |
| BAS94-2 | PDCD6IP PTM Analysis Service |
| BAS94-3 | PDCD6IP-XXX interaction Analysis |
| BAS94-4 | Recombinant PDCD6IP Constructs Generation/Characterization |
| BAS94-5 | In Vitro Ubiquitination of PDCD6IP |
| BAS94-6 | PDCD6IP mRNA Analysis |
If you are interested in our PDCD6IP analysis services, please don't hesitate to contact us to develop custom solution for specific needs. We will work to accommodate your request.
Reference
- Dai, Jie, et al. "Exosomes: key players in cancer and potential therapeutic strategy." Signal transduction and targeted therapy 5.1 (2020): 145. Distributed under CC BY-SA 4.0, without modification.
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