Recombinant Coagulation factor XI Protein (Glu 19-Val 625) [His] (VAng-1411Lsx)
Human Coagulation factor XI (FXI), His tag, is expressed in HEK 293 cells. (Uniprot ID: P03951-1)
Datasheet
Specifications
Source
HEK293 Cells.
Target
FXI
Type
Tumor Antigens
Applications
SDS-PAGE; WB; ELISA.
Formulation
25 mM HEPES, 150 mM NaCl, pH 7.5.
Purity
> 95% pure by SDS-PAGE.
Storage
Store at -20°C to -80°C.
Antigen Information
Introduction
F11 (Coagulation Factor XI) is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality.
Alternative Names
Coagulation factor XI, FXI, PTA, F11
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