A uniCAR [Anti-FITC scFv-28ζ], with a CAR Adaptor [Anti-CD20 Antibody (Rituximab), FITC Labled], a Anti-FITC CAR System (CAR-NR-ZP1031)

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

Fluorescein isothiocyanate (FITC) is a synthetic dye that is physiologically deficient in human body and has been used widely as a flowcytometry marker to label antibodies. The anti-FITC CAR contains two essential elements, one is a FITC-tagged tumor-targeting switch molecule and the other is a transmembrane CAR with an anti-FITC scFv. The FITC-labeled switch molecules form a pseudo-immunological synapse between anti-FITC CAR T cells and tumor cells expressing a given antigen, such as folate receptor or CD19, leading to lysis of the corresponding tumor cells.

Creative Biolabs provides customized Anti-FITC CAR design and construction services. Please contact us for more detailed information.

Datasheet   Add to Cart

CAR Schemeitc


  • CAR Construction
  • Anti-FITC scFv-CD28-CD3ζ
  • Discription of Signaling Cassetes
  • CD28
    CD28 (Cluster of Differentiation 28) is one of the proteins expressed on T cells that provide costimulatory signals required for T cell activation and survival. CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2) proteins which are expressed on antigen-presenting cells (APC). CD28 modulates the primary TCR/CD3ζ signal in a different fashion than the late costimulatory elements OX40 and CD28. CD28 enhances the expression of downstream regulators that impact on T-cell proliferation, death, differentiation, and effector functions. CAR+ T cells containing the CD28 endodomain showed strikingly enhanced sustained T cell activation, growth, survival. And CD28 results in a brightly expressed, stable receptor as the transmembrane domain. Including CD28 costimulatory domains in CARs led to enhanced anti-malignancy efficacy.
    CD3ζ, also known as T-cell receptor zeta, which together with T-cell receptor and CD3γ, δ , ε chain, forms the TCR-CD3 complex. ζ was expressed independently from the complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. CD3-zeta, which contains 3 ITAMs, is the most commonly used endodomain component of CARs. It transmits an activation signal to the T cell after antigen is bound. CD3-zeta may not provide a fully competent activation signal and additional co-stimulatory signaling is needed. For example, chimeric CD28 and OX40 can be used with CD3-zeta to transmit a proliferative/survival signal, or all three can be used together.
  • Vector Name
  • pCDCAR1
  • Vector length
  • ~8kb
  • Vector Type
  • Lentiviral vector
  • Targeting Diseases
  • Acute lymphoblastic leukemia (ALL)

CAR Adaptor

  • Adaptor Target
  • CD20
  • Common Name
  • MS4A1
  • Adaptor Type
  • FITC Labeld Antibody
  • Antibody Host
  • Mouse
  • Antibody Clone
  • Rituximab
  • CAR Adaptor Tag
  • FITC

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

Related Products

Online Inquiry



Call us at:

Online Inquiry

For any technical issues or products/services related questions, please leave your information below. Our team will contact you soon.

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

Key Updates

Receive our latest news and insights.