The biotin-binding immune receptors (BBIR) CAR use the biotin-avidin "lock-key" mechanism for CAR engineering. The BBIR containing dimeric avidin (dcAv BBIR) is used as the extracellular domain linked to an intracellular T cell signaling domain. Avidin was able to efficiently recognize and bind a variety of biotinylated antigen-specific molecules. The biotinylated antigen can be customized as scFv, mAb or tumor-specific ligand. Creative Biolabs provides customized BBIR design and construction services. Please contact us for more detailed information.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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