The split, universal, and programmable (SUPRA) CAR system is a two-component receptor system consisting of a universal receptor with leucine zipper adaptor (zipCAR) on T cells and a separate scFv with leucine zipper adaptor (zipFv) molecule targeting specific antigens. This split "lock-key" structure of SUPRA CAR with leucine zipper adaptors was desighed to enhance the flexibility and controllability of CARs, which has several clinically relevant advantages over a rigid CAR system:
• Antigen targets of one set of zipCAR T cells can be switched, expanded and combined without further modification of the CAR T cells.
• The activities and toxicities of SUPRA CAR T cells can be controlled and fine-tuned.
• Signaling domains and effector cell types can be changed and combined.
Creative Biolabs provides customized SUPRA design and construction services. Please contact us for more detailed information.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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