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Anti-C12H18N4O7 T cell receptor ((B-F3-C1)-2), pCDTCR1 (TCR-YC0165)

rRL-6-CH2OH was shown to trigger MAIT cell activation in an MR1-dependent manner, and it displayed the strongest potency in activating MAIT cells among three structurally related compounds. Thus, the increased MAIT TCR affinity for the E. coli–treated hbMR1 sample correlates with the presence of this ribityl moiety. The TCR recognizes reduced 6-(hydroxymethyl)-8-(1-D-ribityl)lumazine in the context of human MR1.

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Details

  • Target
  • C12H18N4O7
  • Target Species
  • Salmonella enterica subsp. enterica serovar Typhimurium
  • Epitope
  • reduced 6-(hydroxymethyl)-8-(1-D-ribityl)lumazine
  • Format
  • Non-Modified TCR
  • Allele
  • human MR1
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~ 8 kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • B-F3-C1
  • Host Species
  • Human

Target

  • Introduction
  • The pteridine that is lumazine reduced across the C-6,C-7-double bond and substituted with a hydroxymethyl group at C-6 and a 1-D-ribityl group at N-8.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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