rRL-6-CH2OH was shown to trigger MAIT cell activation in an MR1-dependent manner, and it displayed the strongest potency in activating MAIT cells among three structurally related compounds. Thus, the increased MAIT TCR affinity for the E. coli–treated hbMR1 sample correlates with the presence of this ribityl moiety. The TCR recognizes reduced 6-(hydroxymethyl)-8-(1-D-ribityl)lumazine in the context of human MR1.
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