Anti-Human PDGFR alpha (2.796.2) h(CD28-CD3Z) CAR Lentivirus Packaging Kit (XS-0622-YF114)

Name: Anti-Human PDGFR alpha (2.796.2) h(CD28-CD3Z) CAR Lentivirus Packaging Kit
SKU: XS-0622-YF114
Rating: 5 (1 reviews)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

This kit provides a complete lentivirus packaging system to produce anti-PDGFR alpha (2.796.2) h(4-1BB-CD3ζ) CAR lentivirus, which enables CAR-T cells generation to target Human PDGFR alpha. It contains plasmids that express all the viral proteins necessary, and CAR detection reagent, providing a full set of reagents for CAR lentivirus packaging and CAR expression evaluation. The expressed anti-PDGFR alpha CAR lentiviruses are HIV-based, VSV-G pseudotyped lentiviral particles that are ready to be transduced into almost all types of mammalian cells. These viruses constitutively express the scFv portion of anti-PDGFR alpha (2.796.2) linked to 2nd generation CAR containing CD28 and CD3ζ signaling domains. CAR detection reagent can be used to detect the positive expression rate of CAR-T cells after lentiviral transduction.

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Description

Target
PDGFR alpha

Components
This kit contains a CAR lentiviral vector, packaging vectors, CAR detection reagent, and 293 cells.
1. A CAR lentiviral vector
• Anti-PDGFR alpha (2.796.2) h(CD28-CD3ζ) CAR
2. Three packaging vectors
• LentiArt™ pHelp1
• LentiArt™ pHelp2
• LentiArt™ pHelp3
3. CAR detection reagent
4. 293 cells

Size
10 reactions; 20 reactions; 50 reactions

Storage Conditions
For details of the storage requirements, please see the User Manual for instructions.

Applications
CAR lentivirus packaging; CAR lentivirus transfection; CAR-T cell development; CAR-T cell therapy.

CAR Vector

CAR Generation
2nd-generation CAR

Vector Name
pCDCAR1

Vector Length
~8kb

Vector Type
Lentiviral vector

Receptor Construction
scFv-CD28-CD3ζ

Target

Gene Name
PDGFRA

Full Name
Platelet-derived growth factor receptor alpha

scFv
2.796.2

Host Species
Human

Target Species
Human

Gene ID
5156

Uniprot ID
P16234

Target Background
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers.

Synonyms
CD140A; PDGFR2; PDGFR-2

Related Disease
Rhabdomyosarcoma

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Anti-Human PDGFR alpha (2.796.2) h(CD28-CD3Z) CAR Lentivirus Packaging Kit (XS-0622-YF114)

Description

CAR Vector

Target

Customer Reviews and Q&As

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