Anti-KRT8 DNA-encoded mAb (DMAb), pVAX1 (DMAb-1522-CQ)

Datasheet

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

This product is the plasmid containing an encoded anti-KRT8 DMAb sequence. The plasmid can drive transcription and in vivo translation of the desired antibody.

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Specifications

Target
KRT8

Vector Name
pVAX1

Vector Description
pVAX1 was originally designed for the development of DNA vaccines. Its eukaryotic DNA sequences limited to the expression of desired sequence so that minimize the possibility of chromosomal integration. This vector has been widely used for the construction of DMAb plasmid.

Vector Promoter
CMV

Vector Tag or Fusion
Untagged

Delivery Method
Transfection

Cloning Method
Restriction Enzyme ⁄ MCS

Constitutive or Inducible System
Constitutive

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term.

Background
DNA-encoded mAb (DMAb) technology is a novel approach for a direct in vivo production of desired biologically active immunoglobulins according to the plasmid DNA delivery into tissue where the delivered plasmid containing an encoded antibody sequence. Compared with the traditional mAb, DMAb can be functionally equivalent with additional advantages such as expression profiles, glycosylation, as well as no reliance on in vivo tissue culture and costly or time-consuming production systems. The DMAb technology may provide a novel, simple, less frequent, cost-effective approach for therapeutics.

Target

Entrez Gene ID
3856

UniProt ID
P05787

Sub CAT.	DMAb Clone	DMAb Host	Target Species	DMAb Isotype	DMAb Immunogen
DMAb-1522-CQ	35betaH11	Mouse	Human	IgM	A cytoskeletal preparation of the human hepotocellular carcinoma cell line Hep3B
DMAb-1544-FY	AE3	Mouse		IgG	Human epidermal cells
DMAb-1525-CQ	B22.1/B23.1	Mouse	Human	IgG	Cytoskeletal preparation from HeLa epitheliod carcinoma cells (B22.1) and PMC-42 breast carcinoma cells of human origin (B23.1)
DMAb-1526-CQ	C-51	Mouse		IgG1, κ	Cytoskeleton preparation from HeLa cells
DMAb-1527-CQ	H1	Mouse		IgG1	Cytoskeleton preparation containing cytokeratin 8
DMAb-1528-CQ	K8.8	Mouse	Human	IgG1	Keratin preparation from a human carcinoma
DMAb-1529-CQ	K8/383	Mouse	Human	IgG1	Recombinant human cytokeratin 8 protein
DMAb-1530-CQ	KRT8.18/1346	Mouse	Human	IgG1, κ	Cytoskeleton preparation from HeLa cells
DMAb-1531-CQ	KRT8/803	Mouse	Human	IgG1, κ	Recombinant human KRT8 protein
DMAb-1532-CQ	KRT8/899	Mouse		IgM, κ	Recombinant human KRT8 protein
DMAb-1533-CQ	LP3K	Mouse	Human	IgG1	Sonicated cytoskeleton fractions (insoluble in 1% Nonidet-P40) from SV40 transformed neonatal keratinocytes
DMAb-1534-CQ	SPM141	Mouse	Human	IgG1, κ	Keratin preparation from human breast carcinoma MCF-7 cells
DMAb-1535-CQ	SPM192	Mouse	Human	IgG1, κ	Keratin preparation from a human carcinoma
DMAb-1537-CQ	RM266	Rabbit	Human	IgG	A peptide corresponding to the C-terminus of human Cytokeratin 8
DMAb-1539-CQ	R15-K	Rabbit	Human	IgG	Peptide derived from C-terminal region of human cytokeratin 8
DMAb-1542-CQ	B22.1	Mouse		IgG1, κ	Cytoskeletal preparation from HeLa cells
DMAb-1544-CQ	M20	Mouse		IgG1	Keratin isolated from the human breast carcinoma
DMAb-1545-CQ	C-43	Mouse		IgG1, κ	A cytoskeletal preparation from HeLa cells
DMAb-1545-CQ	C-43	Mouse		IgG1
DMAb-0971-WJ	C-43 + DC10	Mouse	Human	IgG	Keratin preparation from a human carcinoma (C-43); PMC-42 human breast carcinoma cells (DC10)
DMAb-0972-WJ	CK 209	Mouse	Human	IgG1, κ
DMAb-1527-CQ	H1	Mouse		IgG1
DMAb-0977-WJ	H1 + TS1	Mouse	Human	IgG	Cytoskeleton preparation containing cytokeratin 8 (H1); Keratin preparation from a human carcinoma (TS1)
DMAb-1528-CQ	K8.8	Mouse	Human	IgG1	Keratin preparation from a human carcinoma
DMAb-0979-WJ	K8.8 + DC10	Mouse	Human	IgG	Keratin preparation from a human carcinoma (K8.8); PMC-42 human breast carcinoma cells (DC10)
DMAb-1529-CQ	K8/383	Mouse	Human	IgG1	Recombinant human cytokeratin 8 protein
DMAb-0982-WJ	KRT8/803 + KRT18/835	Mouse	Human	IgG	Recombinant full-length human KRT8 protein (KRT8/803); Recombinant full-length human KRT18 protein (KRT18/835)
DMAb-0983-WJ	Ks8.7	Mouse		IgG1	Cytokeratin 8 antibody was raised in mouse using cytoskeletal proteins from cultured Hela cells as the immunogen
DMAb-1533-CQ	LP3K	Mouse	Human	IgG1	Sonicated cytoskeleton fractions (insoluble in 1% Nonidet-P40) from SV40 transformed neonatal keratinocytes
DMAb-1542-CQ	B22.1	Mouse		IgG1, κ	Cytoskeletal preparation from HeLa cells
DMAb-1525-CQ	B22.1/B23.1	Mouse	Human	IgG
DMAb-1526-CQ	C-51	Mouse		IgG1
DMAb-1544-CQ	M20	Mouse		IgG1

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Anti-KRT8 DNA-encoded mAb (DMAb), pVAX1 (DMAb-1522-CQ)

Specifications

Target

Customer Reviews and Q&As

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