Anti-MCM2 DNA-encoded mAb (DMAb), pVAX1 (DMAb-2043-FY)

Datasheet

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

This product is the plasmid containing an encoded anti-MCM2 DMAb sequence. The plasmid can drive transcription and in vivo translation of the desired antibody.

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Specifications

Target
MCM2

Vector Name
pVAX1

Vector Description
pVAX1 was originally designed for the development of DNA vaccines. Its eukaryotic DNA sequences limited to the expression of desired sequence so that minimize the possibility of chromosomal integration. This vector has been widely used for the construction of DMAb plasmid.

Vector Promoter
CMV

Vector Tag or Fusion
Untagged

Delivery Method
Transfection

Cloning Method
Restriction Enzyme ⁄ MCS

Constitutive or Inducible System
Constitutive

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term.

Background
DNA-encoded mAb (DMAb) technology is a novel approach for a direct in vivo production of desired biologically active immunoglobulins according to the plasmid DNA delivery into tissue where the delivered plasmid containing an encoded antibody sequence. Compared with the traditional mAb, DMAb can be functionally equivalent with additional advantages such as expression profiles, glycosylation, as well as no reliance on in vivo tissue culture and costly or time-consuming production systems. The DMAb technology may provide a novel, simple, less frequent, cost-effective approach for therapeutics.

Target

Entrez Gene ID
4171

UniProt ID
P49736

Sub CAT.	DMAb Clone	DMAb Host	Target Species	DMAb Isotype	DMAb Immunogen
DMAb-2043-FY	CBFYM-0485	Mouse	Human	IgG2a
DMAb-2044-FY	CBFYM-0604	Mouse	Human	IgG1
DMAb-2045-FY	CBFYM-1885	Mouse	Human	IgG1	Recombinant fragment of human MCM2 expressed in E. coli
DMAb-2046-FY	CBFYM-1886	Rabbit	Human	IgG	A synthetic peptide derived from internal region of Human MCM2 protein
DMAb-2047-FY	CBFYM-1887	Mouse	Human	IgG2a
DMAb-2048-FY	CBFYM-1888	Mouse	Human	IgG2b
DMAb-2049-FY	CBFYM-1889	Mouse	Human	IgG2a, k	Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: TQKFSVMRSM RKTFARYLSF RRDNNELLLF ILKQLVAEQV TYQRNRFGAQ QDTIEVPEKD LVDKARQINI HNLSAFYDSE LFRMNKFSHD LKRKMILQQF
DMAb-2050-FY	CBFYM-1890	Mouse	Human	IgG1	Full length human recombinant protein of human MCM2 (NP_004517) produced in HEK293T cell
DMAb-2051-FY	CBFYM-1891	Mouse	Human	IgG1	Recombinant Human Minichromosome Maintenance Complex Component 2 (Mcm2)
DMAb-2052-FY	CBFYM-1892	Mouse	Human	IgG2a
DMAb-2053-FY	CBFYM-1893	Mouse	Human	IgG1	Recombinant protein corresponding to the N-terminal domain of human MCM2
DMAb-2054-FY	CBFYM-1894	Mouse	Human	IgG	Recombinant fragment of human MCM2
DMAb-2055-FY	CBFYM-1895	Rabbit	Human	IgG

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Anti-MCM2 DNA-encoded mAb (DMAb), pVAX1 (DMAb-2043-FY)

Specifications

Target

Customer Reviews and Q&As

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