Anti-MKI67 DNA-encoded mAb (DMAb), pVAX1 (DMAb-2252-FY)

Datasheet

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

This product is the plasmid containing an encoded anti-MKI67 DMAb sequence. The plasmid can drive transcription and in vivo translation of the desired antibody.

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Specifications

Target
MKI67

Vector Name
pVAX1

Vector Description
pVAX1 was originally designed for the development of DNA vaccines. Its eukaryotic DNA sequences limited to the expression of desired sequence so that minimize the possibility of chromosomal integration. This vector has been widely used for the construction of DMAb plasmid.

Vector Promoter
CMV

Vector Tag or Fusion
Untagged

Delivery Method
Transfection

Cloning Method
Restriction Enzyme ⁄ MCS

Constitutive or Inducible System
Constitutive

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term.

Background
DNA-encoded mAb (DMAb) technology is a novel approach for a direct in vivo production of desired biologically active immunoglobulins according to the plasmid DNA delivery into tissue where the delivered plasmid containing an encoded antibody sequence. Compared with the traditional mAb, DMAb can be functionally equivalent with additional advantages such as expression profiles, glycosylation, as well as no reliance on in vivo tissue culture and costly or time-consuming production systems. The DMAb technology may provide a novel, simple, less frequent, cost-effective approach for therapeutics.

Target

Entrez Gene ID
4288

UniProt ID
P46013

Sub CAT.	DMAb Clone	DMAb Host	Target Species	DMAb Isotype	DMAb Immunogen
DMAb-2252-FY	9C12B2	Mouse	Human	IgG1	Recombinant fragment of Ki167 (aa3118-3256) expressed in E. Coli
DMAb-2253-FY	CBFYM-0650	Rabbit	Human
DMAb-2254-FY	CBFYM-2250	Rat	Human	IgG1	Recombinant protein fragment corresponding to amino acids 1160-1493 of human MKI67 (NP_002408) produced in E. coli
DMAb-2255-FY	CBFYM-2251	Mouse	Human	IgG1	Recombinant protein fragment corresponding to amino acids 2924-3256 of human MKI67 (NP_002408) produced in E. coli
DMAb-2256-FY	CBFYM-2252	Mouse	Human	IgG2a	Recombinant protein corresponding to full length MKI67.Immunogen type: Recombinant protein
DMAb-2257-FY	CBFYM-2253	Mouse	Human	IgG2b, k
DMAb-2258-FY	CBFYM-2254	Mouse	Human	IgG2a, k	Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: RSARQNESSQ PKVAEESGGQ KSAKVLMQNQ KGKGEAGNSD SMCLRSRKTK SQPAASTLES KSVQRVTRSV KRCAENPKKA EDNVCVKKIR TRSHRDSEDI
DMAb-2259-FY	CBFYM-2255	Mouse	Human	IgG2b	Recombinant protein expressed in E.coli corresponding to amino acids 1-250 of human MKI67
DMAb-2260-FY	CBFYM-2256	Mouse	Human	IgG1	Nuclear protein preparation from the human cell line U937.50
DMAb-2261-FY	CBFYM-2257	Rabbit	Human	IgG	A peptide corresponding to the internal region of human Ki67

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Anti-MKI67 DNA-encoded mAb (DMAb), pVAX1 (DMAb-2252-FY)

Specifications

Target

Customer Reviews and Q&As

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