Anti-NBN DNA-encoded mAb (DMAb), pVAX1 (DMAb-1181-WJ)

Datasheet

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

This product is the plasmid containing an encoded anti-NBN DMAb sequence. The plasmid can drive transcription and in vivo translation of the desired antibody.

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Specifications

Target
NBN

Vector Name
pVAX1

Vector Description
pVAX1 was originally designed for the development of DNA vaccines. Its eukaryotic DNA sequences limited to the expression of desired sequence so that minimize the possibility of chromosomal integration. This vector has been widely used for the construction of DMAb plasmid.

Vector Promoter
CMV

Vector Tag or Fusion
Untagged

Delivery Method
Transfection

Cloning Method
Restriction Enzyme ⁄ MCS

Constitutive or Inducible System
Constitutive

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term.

Background
DNA-encoded mAb (DMAb) technology is a novel approach for a direct in vivo production of desired biologically active immunoglobulins according to the plasmid DNA delivery into tissue where the delivered plasmid containing an encoded antibody sequence. Compared with the traditional mAb, DMAb can be functionally equivalent with additional advantages such as expression profiles, glycosylation, as well as no reliance on in vivo tissue culture and costly or time-consuming production systems. The DMAb technology may provide a novel, simple, less frequent, cost-effective approach for therapeutics.

Target

Entrez Gene ID
4683

UniProt ID
O60934

Sub CAT.	DMAb Clone	DMAb Host	Target Species	DMAb Isotype	DMAb Immunogen
DMAb-0860-WJ	1D7	Mouse		IgG1	The complete coding region of the human p95/NBS1 expressed in E. coli.
DMAb-342-YC	3E4	Mouse	Human	IgG2a, κ	Partial recombinant corresponding to aa645-754 from human NBN (NP_002476) with GST tag. MW of the GST tag alone is 26kD
DMAb-033-YC	8E6	Mouse	Human	IgG1	Human recombinant protein fragment corresponding to amino acids 183-460 of human NBN (NP_002476) produced in E.coli
DMAb-1187-WJ	8E7	Mouse	Human	IgG1	Human recombinant protein fragment corresponding to amino acids 183-460 of human NBN (NP_002476)produced in E. coli
DMAb-0818-LY	2E9	Mouse	Human	IgG1	Human recombinant protein fragment corresponding to amino acids 461-754 of human NBN (NP_002476) produced in E.coli
DMAb-659-YC	2E10	Mouse	Human	IgG1	Human recombinant protein fragment corresponding to amino acids 183-460 of human NBN (NP_002476) produced in E.coli
DMAb-1190-WJ	5E11	Mouse	Human	IgG1	Human recombinant protein fragment corresponding to amino acids 183-460 of human NBN (NP_002476) produced in E.coli
DMAb-1191-WJ	6E11	Mouse	Human	IgG2a	Human recombinant protein fragment corresponding to amino acids 183-460 of human NBN (NP_002476)produced in E. coli
DMAb-607-YC	1C3	Mouse		IgG1	The complete coding region of the human p95/NBS1 expressed in E. coli
DMAb-1323-LY	1C9	Mouse	Human	IgG1	Human recombinant protein fragment corresponding to amino acids 461-754 of human NBN (NP_002476) produced in E.coli
DMAb-370-YC	1F11	Mouse	Human	IgG1	Human recombinant protein fragment corresponding to amino acids 461-754 of human NBN (NP_002476) produced in E.coli
DMAb-0015-WJ	1G1	Mouse	Human	IgG2a	Human recombinant protein fragment corresponding to amino acids 461-754 of human NBN (NP_002476) produced in E.coli
DMAb-602-YC	1G10	Mouse	Human	IgG1	Human recombinant protein fragment corresponding to amino acids 461-754 of human NBN (NP_002476) produced in E.coli
DMAb-497-YC	1G8	Mouse	Human	IgG2b	Human recombinant protein fragment corresponding to amino acids 183-460 of human NBN (NP_002476)produced in E.coli
DMAb-510-YC	2C7	Mouse		IgG2a, κ	NBN (NP_002476, 645aa-754aa) partial recombinant protein with GST tag. MW of the GST tag alone is 26kD
DMAb-1201-WJ	2F5	Mouse	Human	IgG2b	Human recombinant protein fragment corresponding to amino acids 183-460 of human NBN (NP_002476) produced in E.coli
DMAb-0156-YJ	2G4	Mouse	Human	IgG1	Human recombinant protein fragment corresponding to amino acids 183-460 of human NBN (NP_002476) produced in E.coli
DMAb-1203-WJ	2T17	Mouse	Human	IgG2a	Recognizes phosphorylated Nibrin/nbs1 (Ser343), Mr ~100kD, which exhibits slower mobility in SDS-PAGE relative to unphosphorylated Nibrin
DMAb-0958-LY	3A2	Mouse	Human	IgG1	Human recombinant protein fragment corresponding to amino acids 461-754 of human NBN (NP_002476) produced in E.coli
DMAb-3597CQ	3A4	Mouse	Human	IgG2a	Human recombinant protein fragment corresponding to amino acids 183-460 of human NBN (NP_002476) produced in E.coli
DMAb-M137-YC	3A9	Mouse	Human	IgG2a	Human recombinant protein fragment corresponding to amino acids 461-754 of human NBN (NP_002476) produced in E.coli
DMAb-0509-FY	3C12	Mouse	Human	IgG2a	Human recombinant protein fragment corresponding to amino acids 183-460 of human NBN (NP_002476) produced in E.coli
DMAb-0087-YJ	3G3	Mouse	Human	IgG1	Human recombinant protein fragment corresponding to amino acids 183-460 of human NBN (NP_002476)produced in E.coli
DMAb-1210-WJ	3J15	Mouse	Human	IgG	GST fusion protein corresponding to residues 420-774 of human Nibrin
DMAb-1211-WJ	4H9	Mouse	Human	IgG1
DMAb-1212-WJ	5A6	Mouse	Human	IgG1	Human recombinant protein fragment corresponding to amino acids 461-754 of human NBN (NP_002476) produced in E.coli
DMAb-1111-CQ	6A3	Mouse	Human	IgG1	Human recombinant protein fragment corresponding to amino acids 183-460 of human NBN (NP_002476) produced in E.coli
DMAb-1122-WJ	6D10	Mouse	Human	IgG1	Human recombinant protein fragment corresponding to amino acids 183-460 of human NBN (NP_002476) produced in E.coli
DMAb-1215-WJ	6H7	Mouse	Human	IgG1	Human recombinant protein fragment corresponding to amino acids 183-460 of human NBN (NP_002476)produced in E.coli
DMAb-401-YC	7D5	Mouse	Human	IgG1	Human recombinant protein fragment corresponding to amino acids 183-460 of human NBN (NP_002476) produced in E.coli
DMAb-1217-WJ	7E4C2	Mouse	Human	IgG2a	Purified recombinant fragment of human NBN (AA: 467-615) expressed in E. Coli
DMAb-0655-WJ	9H2	Mouse	Human	IgG1	Human recombinant protein fragment corresponding to amino acids 183-460 of human NBN (NP_002476) produced in E.coli
DMAb-0739-WJ	B-5	Mouse	Human
DMAb-1220-WJ	E11	Mouse	Human	IgG2a	Human recombinant protein fragment corresponding to amino acids 183-460 of human NBN (NP_002476)produced in E.coli
DMAb-1221-WJ	E7	Mouse	Human	IgG1	Human recombinant protein fragment corresponding to amino acids 183-460 of human NBN (NP_002476)produced in E.coli
DMAb-1222-WJ	G3	Mouse	Human	IgG1	Human recombinant protein fragment corresponding to amino acids 183-460 of human NBN (NP_002476)produced in E.coli
DMAb-169-YC	G8	Mouse	Human	IgG2b	Human recombinant protein fragment corresponding to amino acids 183-460 of human NBN (NP_002476)produced in E.coli
DMAb-894-YC	H7	Mouse	Human	IgG1	Human recombinant protein fragment corresponding to amino acids 183-460 of human NBN (NP_002476)produced in E.coli
DMAb-1227-WJ	Y112	Rabbit		IgG	A synthetic peptide corresponding to residues near C-terminus of human Nibrin was used as immunogen

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Anti-NBN DNA-encoded mAb (DMAb), pVAX1 (DMAb-1181-WJ)

Specifications

Target

Customer Reviews and Q&As

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