Anti-NUMB DNA-encoded mAb (DMAb), pVAX1 (DMAb-1811-WJ)

Datasheet

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

This product is the plasmid containing an encoded anti-NUMB DMAb sequence. The plasmid can drive transcription and in vivo translation of the desired antibody.

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Specifications

Target
NUMB

Vector Name
pVAX1

Vector Description
pVAX1 was originally designed for the development of DNA vaccines. Its eukaryotic DNA sequences limited to the expression of desired sequence so that minimize the possibility of chromosomal integration. This vector has been widely used for the construction of DMAb plasmid.

Vector Promoter
CMV

Vector Tag or Fusion
Untagged

Delivery Method
Transfection

Cloning Method
Restriction Enzyme ⁄ MCS

Constitutive or Inducible System
Constitutive

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term.

Background
DNA-encoded mAb (DMAb) technology is a novel approach for a direct in vivo production of desired biologically active immunoglobulins according to the plasmid DNA delivery into tissue where the delivered plasmid containing an encoded antibody sequence. Compared with the traditional mAb, DMAb can be functionally equivalent with additional advantages such as expression profiles, glycosylation, as well as no reliance on in vivo tissue culture and costly or time-consuming production systems. The DMAb technology may provide a novel, simple, less frequent, cost-effective approach for therapeutics.

Target

Entrez Gene ID
8650

UniProt ID
P49757

Sub CAT.	DMAb Clone	DMAb Host	Target Species	DMAb Isotype	DMAb Immunogen
DMAb-427-YC	1E3	Mouse	Human	IgG2a	Human recombinant protein fragment corresponding to amino acids 1-365 of human NUMB (NP_001005744) produced in E.coli
DMAb-355-YC	3E5	Mouse		IgG1	Human recombinant protein fragment corresponding to amino acids 1-365 of human NUMB (NP_001005744) produced in E.coli
DMAb-660-YC	2E8	Mouse	Human	IgG1	Human recombinant protein fragment corresponding to amino acids 1-365 of human NUMB (NP_001005744) produced in E.coli
DMAb-010-YC	1A11	Mouse	Human	IgG1	Human recombinant protein fragment corresponding to amino acids 1-365 of human NUMB (NP_001005744) produced in E.coli
DMAb-014-YC	1A12	Mouse	Human	IgG2a	Human recombinant protein fragment corresponding to amino acids 1-365 of human NUMB (NP_001005744) produced in E.coli
DMAb-325-YC	1A7	Mouse	Human	IgG1	Full length human recombinant protein of human NUMB (NP_003735) produced in HEK293T cell
DMAb-869-YC	1B5	Mouse	Human	IgG2a	Human recombinant protein fragment corresponding to amino acids 1-365 of human NUMB (NP_001005744) produced in E.coli
DMAb-1190-LY	2B9	Mouse	Human	IgG1	Human recombinant protein fragment corresponding to amino acids 1-365 of human NUMB (NP_001005744) produced in E.coli
DMAb-0002-YJ	2C4	Mouse	Human	IgG1	Full length human recombinant protein of human NUMB (NP_003735) produced in HEK293T cell
DMAb-0617-YY	2F1	Mouse	Human	IgG1	Human recombinant protein fragment corresponding to amino acids 1-365 of human NUMB (NP_001005744) produced in E.coli
DMAb-416-YC	2G1	Mouse	Human	IgG2a	Human recombinant protein fragment corresponding to amino acids 1-365 of human NUMB (NP_001005744) produced in E.coli
DMAb-1825-WJ	2G12B7	Mouse		IgG2a
DMAb-420-YC	3B2	Mouse	Human	IgG1	Human recombinant protein fragment corresponding to amino acids 1-365 of human NUMB (NP_001005744) produced in E.coli
DMAb-671-YC	3H8	Mouse	Human	IgG2a	Human recombinant protein fragment corresponding to amino acids 1-365 of human NUMB (NP_001005744) produced in E.coli
DMAb-0338-LY	4C6	Mouse	Human	IgG2a	Human recombinant protein fragment corresponding to amino acids 1-365 of human NUMB (NP_001005744) produced in E.coli
DMAb-1830-WJ	4D10	Mouse	Human	IgG2b	Human recombinant protein fragment corresponding to amino acids 1-365 of human NUMB (NP_001005744) produced in E.coli
DMAb-1831-WJ	4D3	Mouse	Human	IgG1	Human recombinant protein fragment corresponding to amino acids 1-365 of human NUMB (NP_001005744) produced in E.coli
DMAb-664-YC	4F3	Mouse	Human	IgG2a	Full length human recombinant protein of human NUMB(NP_003735) produced in HEK293T cell
DMAb-704-YC	4H2	Mouse	Human	IgG1	Human recombinant protein fragment corresponding to amino acids 1-365 of human NUMB (NP_001005744) produced in E.coli
DMAb-1084-CQ	5A9	Mouse	Human	IgG1	Full length human recombinant protein of human NUMB(NP_003735) produced in HEK293T cell
DMAb-1835-WJ	5C5	Mouse	Human	IgG1	Human recombinant protein fragment corresponding to amino acids 1-365 of human NUMB (NP_001005744) produced in E.coli
DMAb-1836-WJ	5F6E1	Mouse	Human	IgG2a
DMAb-1837-WJ	6B2	Mouse	Human	IgG2a	Full length human recombinant protein of human NUMB (NP_003735) produced in HEK293T cell
DMAb-1839-WJ	C29G11	Rabbit	Human	IgG
DMAb-1840-WJ	C44B4	Rabbit	Human
DMAb-1841-WJ	D5C2	Rabbit		IgG
DMAb-1843-WJ	S.925.4	Rabbit	Human	IgG	Synthetic peptide corresponding to residues surrounding Phe482 of human Numb protein
DMAb-1844-WJ	T.873.4	Rabbit		IgG	Synthetic peptide corresponding to residues surrounding Ala570 of human Numb protein

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Anti-NUMB DNA-encoded mAb (DMAb), pVAX1 (DMAb-1811-WJ)

Specifications

Target

Customer Reviews and Q&As

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