Anti-SIGIRR DNA-encoded mAb (DMAb), pVAX1 (DMAb-2363-CQ)

Datasheet

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

This product is the plasmid containing an encoded anti-SIGIRR DMAb sequence. The plasmid can drive transcription and in vivo translation of the desired antibody.

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Specifications

Target
SIGIRR

Vector Name
pVAX1

Vector Description
pVAX1 was originally designed for the development of DNA vaccines. Its eukaryotic DNA sequences limited to the expression of desired sequence so that minimize the possibility of chromosomal integration. This vector has been widely used for the construction of DMAb plasmid.

Vector Promoter
CMV

Vector Tag or Fusion
Untagged

Delivery Method
Transfection

Cloning Method
Restriction Enzyme ⁄ MCS

Constitutive or Inducible System
Constitutive

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term.

Background
DNA-encoded mAb (DMAb) technology is a novel approach for a direct in vivo production of desired biologically active immunoglobulins according to the plasmid DNA delivery into tissue where the delivered plasmid containing an encoded antibody sequence. Compared with the traditional mAb, DMAb can be functionally equivalent with additional advantages such as expression profiles, glycosylation, as well as no reliance on in vivo tissue culture and costly or time-consuming production systems. The DMAb technology may provide a novel, simple, less frequent, cost-effective approach for therapeutics.

Target

Entrez Gene ID
59307

UniProt ID
Q6IA17

Sub CAT.	DMAb Clone	DMAb Host	Target Species	DMAb Isotype	DMAb Immunogen
DMAb-2363-CQ	CBXS-3616	Mouse		IgG1	Human recombinant SIGIRR EC domain
DMAb-2364-CQ	CBXS-4664	Rat		IgG2	Mouse recombinant protein of SIGIRR extracellular domain
DMAb-2365-CQ	CBXS-0365	Mouse		IgG2a
DMAb-2366-CQ	CBXS-1079	Rabbit		IgG	Recombinant Human SIGIRR/TIR8 Protein
DMAb-2367-CQ	CBXS-1091	Rabbit		IgG	Recombinant Human SIGIRR/TIR8 protein
DMAb-2368-CQ	CBXS-1326	Rabbit		IgG
DMAb-2369-CQ	CBXS-1678	Rat		IgG1	NS0-derived recombinant mouse SIGIRR, Met1-His117, Accession # Q9JLZ8
DMAb-2370-CQ	CBXS-1679	Mouse		IgG2a	NS0-derived recombinant human SIGIRR, Met1-His118, Accession # Q6IA17
DMAb-2371-CQ	CBXS-2369	Mouse		IgG2a	Recombinant protein corresponding to Met1-His118 of human SIGIRR expressed in NS0 cells (Q6IA17)
DMAb-2372-CQ	CBXS-2575	Mouse		IgG1	Recombinant protein corresponding to human SIGIRR extracellular domain
DMAb-2373-CQ	CBXS-2576	Rat		IgG2	Recombinant protein corresponding to mouse SIGIRR
DMAb-2374-CQ	CBXS-3146	Mouse		IgM, κ	Full length recombinant corresponding to aa1-411 from human SIGIRR (AAH03591) with GST tag

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Anti-SIGIRR DNA-encoded mAb (DMAb), pVAX1 (DMAb-2363-CQ)

Specifications

Target

Customer Reviews and Q&As

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