It was created a transgenic mouse that expressed exclusively the TCR α-chain of a VSV-specific, H-2Kb-restricted T cell clone (N30.7, Vα2/Vβ13). When the transgenic mice were immunized with the VSV peptide, Vβ13 was again the predominant Vβ element present in VSV-specific CTL populations. However, the TCR Vβ usage was profoundly altered when these transgenic mice were immunized with peptides carrying single replacements near the C terminus of VSV. Peptides with replacements at the N terminus of VSV were able to induce a strong cytotoxic response but did not alter the TCR Vβ usage.
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