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CAR-T Lipid Nanoparticle Encapsulation Service

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The use of lipid nanoparticles (LNPs) technology in CAR-T therapy represents a significant advancement, offering improved delivery, reduced immunogenicity, and scalable manufacturing options. These advantages collectively enhance the efficacy, safety, and accessibility of CAR-T therapies, promising better outcomes for patients with various forms of cancer. At Creative Biolabs, we offer a comprehensive suite of IVT RNA and LNP manufacturing services designed to maximize the efficacy and safety of CAR-T therapy.

LNPs: A Versatile Drug Delivery Platform

LNPs have emerged as a critical technology in the delivery of therapeutic agents, including nucleic acids such as RNA. At Creative Biolabs, we offer advanced LNP encapsulation services designed to optimize the delivery and functionality of IVT RNA in CAR-T cell therapy. Our services are meticulously designed to support the development and production of high-quality LNPs that are essential for the encapsulation and delivery of mRNA and other genetic cargo involved in CAR-T therapy. By leveraging our state-of-the-art technology and expertise, we ensure that the LNPs produced are highly efficient, stable, and capable of delivering their cargo with high specificity and minimal side effects. Our one-stop service covers every stage of LNP production, from initial design and formulation to scaling up for clinical and commercial use, ensuring that each product meets rigorous quality standards and regulatory requirements.

Fig.1 The benefits of CAR-LNP. (Khawar, et al., 2024)Fig.1 The advantages of CAR-LNP.1

Advanced LNP Encapsulation Services

LNPs have emerged as a critical technology in the delivery of therapeutic agents, including nucleic acids such as RNA. At Creative Biolabs, we offer advanced LNP encapsulation services designed to optimize the delivery and functionality of IVT RNA in CAR-T cell therapy. Our services are meticulously designed to support the development and production of high-quality LNPs that are essential for the encapsulation and delivery of mRNA and other genetic cargo involved in CAR-T therapy. By leveraging our state-of-the-art technology and expertise, we ensure that the LNPs produced are highly efficient, stable, and capable of delivering their cargo with high specificity and minimal side effects. Our one-stop service covers every stage of LNP production, from initial design and formulation to scaling up for clinical and commercial use, ensuring that each product meets rigorous quality standards and regulatory requirements.

We utilize state-of-the-art techniques and materials to create tailor-made solutions for LNP encapsulation, including:

  • LNP Formation: Our expert team specializes in designing and optimizing lipid nanoparticle formulations to ensure the highest level of efficacy and stability for your applications. Our LNP formulation process involves the careful mixing of lipids under controlled conditions to form stable nanoparticles.
  • Encapsulation Process: We provide meticulous preparation services for lipid nanoparticles, ensuring precise and reproducible production processes. The RNA encapsulation is achieved through techniques like ethanol injection or microfluidics, wherein the IVT RNA is introduced into the lipid mixture, resulting in the formation of RNA-loaded LNPs. Our preparation processes are designed to achieve the desired particle size, uniformity, and encapsulation efficiency.
  • Characterization and Quality Control: The encapsulated LNPs are then subjected to a battery of characterization tests. Parameters such as particle size distribution, surface charge, RNA encapsulation efficiency, and stability are meticulously evaluated. This ensures that the LNPs exhibit the desired biophysical properties for efficient cellular uptake and transfection.

Fig.2 LNP Encapsulation service. (Creative Biolabs original)

Advantages of Our LNP Encapsulation Services

  • Cutting-edge technology
  • High Encapsulation Efficiency
  • Personalized service
  • Strict quality control
  • Rich expertise and professional support

Reference

  1. Khawar, Muhammad Babar, et al. "Steering the course of CAR T cell therapy with lipid nanoparticles." Journal of Nanobiotechnology 22.1 (2024): 380. Distributed under Open Access license CC BY 4.0, without modification.
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