Corticosteroids Discovery Service for CRS Management

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Creative Biolabs is a contract research organisation (CRO) that provides drug discovery and development solutions using its world-renowned expertise in drug discovery, immunology, and cancer therapy. Founded in New York in 2007, Creative Biolabs operates in state-of-the-art facilities to provide superior quality data to support your drug discovery program.

Cytokine Release Syndrome

Cytokine release syndrome (CRS) is a form of systemic inflammatory response syndrome which occurs in some diseases or infections. CRS is also an adverse effect of immunotherapies, including monoclonal antibody drugs, T cell therapy (see Fig.1). If the CRS is severe, the CRS will be called cytokine storms which will cause high fever, hypotension, hypoxia, occasionally seizures and cerebral oedema, etc. which are harmful to patients. Along with the wide application of immunotherapies in clinical cases, it becomes necessary to explore more treatment approaches to control the toxicities caused by immunotherapies. With well-known immunosuppressive functions, corticosteroids are used following the infusion of CAR-T cell therapy in clinical cases when the toxicities are refractory to cytokine targeting therapies.

Fig.1 Symptoms of CRS.¹

Corticosteroids Discovery for CRS Management

Currently, the standard interventions to control CRS include 10 mg dexamethasone intravenous every 6 hours and 1mg/kg methylprednisolone intravenous every 12 hours. It has been demonstrated that low dose and short regimen of corticosteroids do not impair the proliferation or cytotoxicity of CAR-T cells. Taken together, corticosteroids are valuable approaches to treat CRS. To support the successful application of innovative cancer immunotherapies, it's vital to manage the CRS to maintain under the safe range. Hence, Creative Biolabs launched a series of solutions to offer a broad range of drug discovery and development services to manage the CRS. Here we offer discovery and development services for corticosteroids drugs which are effective to manage moderate-to-severe CRS.

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Our priority is your success
Deliver increased value at a lower cost
Freeing up time to focus on your core drug discovery and development offerings
Add value to your program offering with innovative and technology solutions you can trust

By partnering with Creative Biolabs, you can combine your expertise with our leading technology platforms and rich experiences that will allow you to own a truly full-service solution. We are experienced in providing tailored solutions designed to meet your specific requirements. Please contact us to learn more about how we can be involved in your program.

Reference

Mostafa Kamel, Yasser. "CAR-T Therapy, the End of a Chapter or the Beginning of a New One?." Cancers 13.4 (2021): 853. Distributed under Open Access license CC BY 4.0, without modification.

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

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