Donor-dependent In Vivo Mouse Model Development Service

Donor-dependent in vivo mouse models provide indispensable value in cytokine profiling, as they enable dynamic and quantitative assessment of donor-specific risks such as CRS and immune activation status during treatment. Creative Biolabs' Donor-dependent In Vivo Mouse Model Development Service leverages a range of highly humanized models to establish an advanced platform that faithfully recapitulates human tumor-immune interactions. We are committed to delivering integrated and highly predictive evaluations of both immunotherapeutic efficacy and safety, thereby overcoming the limitations associated with conventional model systems.

Introduction

Donor-dependent in vivo mouse models are advanced preclinical platforms established by engrafting functional human immune cells from specific donors into immunodeficient mice, thereby recapitulating the human immune system within an in vivo setting to evaluate immunotherapies. These models primarily include the Hu-PBMC, Hu-HSC, and Hu-BLT systems, each distinguished by the source of immune cells and the resulting immune profile. A key advantage of such donor-dependent models lies in their capacity to provide integrated, donor-specific cytokine profiling, enabling precise assessment of both therapeutic efficacy and immune-related adverse events, such as CRS, thereby supporting more predictive and translatable immuno-oncology research.

Fig.1 Development of donor-specific humanized mouse models for immuno-oncology research.¹

Donor-dependent In Vivo Mouse Model Development Service at Creative Biolabs

Creative Biolabs' Donor-dependent In Vivo Mouse Model Development Service utilizes a range of highly humanized mouse models to accurately recapitulate the complexity of the human immune system and its interactions with tumors. Our platform enables a systematic and quantifiable assessment of critical parameters during therapy, including CRS risk and anti-tumor efficacy, thereby delivering predictive preclinical data to support the efficacy and safety evaluation of immunotherapies.

What we can offer

We provide donor-specific immune cells to reconstitute murine models, enabling you to faithfully recapitulate the human immune microenvironment and establish a robust platform for cytokine profiling and analysis.

Our Service Process

Creative Biolabs follows a transparent, meticulously planned workflow, ensuring clear expectations and timely project completion.

Key Advantages

• Expert-Guided Project Design: Benefit from a complimentary, in-depth consultation with our scientific team to co-create a robust study design tailored to your specific immunotherapy candidate and research objectives.
• Strategic Program Planning: We collaborate with you to develop a comprehensive project strategy, ensuring that in vivo studies are strategically aligned to generate the most critical and decision-driving data for your program's progression.
• Advanced Models for Complex Human Biology: Leverage our capabilities to incorporate further differentiated immune cells, enabling the development of sophisticated models that more accurately mirror the complex human immune response and tumor microenvironment.

FAQ

Why Choose Us?

As a global leader in in vivo toxicology and efficacy testing, Creative Biolabs possesses profound expertise in xenograft models and immuno-oncology. Our distinguished Donor-dependent In Vivo Mouse Model Development Service is uniquely designed to address key clinical challenges, including patient variability and combination therapy, by delivering exceptional predictive power. We go beyond conventional survival analyses to provide mechanistic insights that are critical for optimal candidate selection.

Customer Reviews

"Using Creative Biolabs' Donor-dependent In Vivo Mouse Model Development Service in our research has significantly improved our ability to distinguish between low- and high-risk therapy. The clear donor stratification data provided a level of predictability that traditional in vitro assays completely lacked, saving us months of development time."— Emi** R****.

"The dual imaging and cytokine analysis facilitated a true understanding of the link between tumor kill and CRS onset. The detailed data was instrumental in justifying our starting dose for our application, directly addressing our concerns regarding therapeutic window. Creative Biolabs' quick turnaround was essential."— Dr. H*ng L.

"We utilized this service to test our CAR-T and a novel immune-modulating drug combination. The ability to track synergistic cytokine release in vivo gave us the confidence to move forward with the combination regimen, something we couldn't achieve with co-cultures."— Feli** S****h.

How to contact us?

Based on our donor-dependent in vivo mouse model development service, we deliver a dual, integrated assessment of both therapeutic efficacy and donor-specific CRS risk, enabling more informed decision-making and helping reduce the likelihood of clinical failure.

We invite you to contact our team for further information and to discuss your specific project requirements.

Reference

1. Rojas, Carolina et al. "Humanized Mouse Models for the Study of Periodontitis: An Opportunity to Elucidate Unresolved Aspects of Its Immunopathogenesis and Analyze New Immunotherapeutic Strategies." Frontiers in immunology vol. 12 663328. Distributed under Open Access License CC BY 4.0, without modification. https://doi.org/10.3389/fimmu.2021.663328.